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Titolo:
Lipase-catalyzed asymmetrization of diacetate of meso-2-(2-propynyl)cyclohexane-1,2,3-triol toward the total synthesis of aquayamycin
Autore:
Matsumoto, T; Konegawa, T; Yamaguchi, H; Nakamura, T; Sugai, T; Suzuki, K;
Indirizzi:
Tokyo Inst Technol, Dept Chem, Meguro Ku, Tokyo 1528551, Japan Tokyo Inst Technol Tokyo Japan 1528551 , Meguro Ku, Tokyo 1528551, Japan Japan Sci & Technol Corp, JST, CREST, Tokyo 1528551, Japan Japan Sci & Technol Corp Tokyo Japan 1528551 CREST, Tokyo 1528551, Japan Keio Univ, Dept Elect Engn, Kohoku Ku, Yokohama, Kanagawa 2238552, Japan Keio Univ Yokohama Kanagawa Japan 2238552 kohama, Kanagawa 2238552, Japan
Titolo Testata:
SYNLETT
fascicolo: 10, , anno: 2001,
pagine: 1650 - 1652
SICI:
0936-5214(200110):10<1650:LAODOM>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENZYMATIC ASYMMETRIZATION; ESTERASE;
Keywords:
asymmetrization; hydrolysis; enzyme; meso compound; total synthesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Matsumoto, T Tokyo Inst Technol, Dept Chem, Meguro Ku, Tokyo 1528551, Japan Tokyo Inst Technol Tokyo Japan 1528551 Tokyo 1528551, Japan
Citazione:
T. Matsumoto et al., "Lipase-catalyzed asymmetrization of diacetate of meso-2-(2-propynyl)cyclohexane-1,2,3-triol toward the total synthesis of aquayamycin", SYNLETT, (10), 2001, pp. 1650-1652

Abstract

The diacetate of meso-2-(2-propynyl)cyclohexane-1,2,3-triol was efficiently asymmetrized by hydrolysis with Candida antarctica lipase to give the corresponding mono-acetate in enantiomerically pure form, which was used as the starting material for the total synthesis of aquayamycin. Application of the protocol to the related cyclohexanetriols is also described.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 17:25:45