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Titolo:
Association between infection with Helicobacter pylori and Chlamydia pneumoniae and risk of ischemic stroke subtypes - Results from a population-based case-control study
Autore:
Heuschmann, PU; Neureiter, D; Gesslein, M; Craiovan, B; Maass, M; Faller, G; Beck, G; Neundoerfer, B; Kolominsky-Rabas, PL;
Indirizzi:
Univ Erlangen Nurnberg, Unit Stroke Res & Publ Hlth Med, Dept Neurol, D-8520 Erlangen, Germany Univ Erlangen Nurnberg Erlangen Germany D-8520 D-8520 Erlangen, Germany Univ Erlangen Nurnberg, Dept Pathol, D-8520 Erlangen, Germany Univ Erlangen Nurnberg Erlangen Germany D-8520 D-8520 Erlangen, Germany Univ Erlangen Nurnberg, Dept Psychiat, Inst Neurobiochem, D-8520 Erlangen,Germany Univ Erlangen Nurnberg Erlangen Germany D-8520 , D-8520 Erlangen,Germany Med Univ Lubeck, Inst Med Microbiol & Hyg, D-23538 Lubeck, Germany Med Univ Lubeck Lubeck Germany D-23538 ol & Hyg, D-23538 Lubeck, Germany
Titolo Testata:
STROKE
fascicolo: 10, volume: 32, anno: 2001,
pagine: 2253 - 2258
SICI:
0039-2499(200110)32:10<2253:ABIWHP>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; C-REACTIVE PROTEIN; CEREBROVASCULAR-DISEASE; CARDIOVASCULAR-DISEASE; ANTIBODY-TITERS; ARTERY DISEASE; CASE-FATALITY; CYTOMEGALOVIRUS; ATHEROSCLEROSIS; MORTALITY;
Keywords:
Chlamydia pneumoniae; Helicobacter pylori; seroepidemiologic studies; stroke;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Heuschmann, PU Unit Publ Hlth Med, Schwabachanlage 6, D-91054 Erlangen, Germany Unit Publ Hlth Med Schwabachanlage 6 Erlangen Germany D-91054
Citazione:
P.U. Heuschmann et al., "Association between infection with Helicobacter pylori and Chlamydia pneumoniae and risk of ischemic stroke subtypes - Results from a population-based case-control study", STROKE, 32(10), 2001, pp. 2253-2258

Abstract

Background and Purpose-Helicobacter pylori and Chlamydia pneumoniae have been associated epidemiologically and pathogenetically with coronary atherosclerosis. However, population-based data on chronic infection and stroke are lacking. Therefore, we investigated the association of both bacterial pathogens and ischemic stroke subtypes in a population-based case-control study. Methods-Patients with first ischemic stroke in the population-based Erlangen Stroke Project were collected as cases. Neighborhood controls were drawnfrom the study population, matched for age, sex, and place of residence. IgG antibodies to H pylori were measured by enzyme immunoassay, and IgG antibodies to C pneumoniae were measured by microimmunofluorescence technique. Conditional logistic regression was used. Analyses were stratified for etiologic stroke subtypes according to Trial of Org 10172 in Acute Stroke Treatment (TOAST) criteria. Results-A total of 145 case and 260 control subjects were included. Chronic H pylori infection was associated with a higher risk of stroke caused by small-artery occlusion (adjusted odds ratio, 3.31; 95% CI, 1.15 to 9.56) and a lower risk of cardioembolic stroke (adjusted odds ratio, 0.21; 95% Cl, 0.06 to 0.71). Overall, elevated H pylori as well as elevated C pneumoniae antibodies were not associated with ischemic stroke. Conclusions-Our population-based study does not provide evidence of any strong association between the immune response to C pneumoniae as a marker ofprior infection and ischemic stroke. Further studies are required to reveal the role of chronic H pylori infection as an independent risk factor for the subgroup small-artery occlusion.

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Documento generato il 09/04/20 alle ore 13:31:51