Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Nociceptive responses to chronic stress of restraint and noxious stimuli in sucrose fed rats
Autore:
Mukherjee, K; Mathur, R; Nayar, U;
Indirizzi:
All India Inst Med Sci, Dept Physiol, Neurophysiol Lab, New Delhi 110029, India All India Inst Med Sci New Delhi India 110029 b, New Delhi 110029, India
Titolo Testata:
STRESS AND HEALTH
fascicolo: 5, volume: 17, anno: 2001,
pagine: 297 - 305
SICI:
1532-3005(200110)17:5<297:NRTCSO>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED ANALGESIA; PAIN; DYNORPHIN; TOLERANCE; NALOXONE; EXPOSURE; PEPTIDE; BRAIN;
Keywords:
stress induced analgesia; hot plate; threshold of tail flick; sucrose feeding; palatability; tail flick latency; paw lick latency; vocalization after discharge; chronic pain stress model;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Mathur, R All India Inst Med Sci, Dept Physiol, Neurophysiol Lab, New Delhi 110029, India All India Inst Med Sci New Delhi India 110029 hi 110029, India
Citazione:
K. Mukherjee et al., "Nociceptive responses to chronic stress of restraint and noxious stimuli in sucrose fed rats", STRESS HEAL, 17(5), 2001, pp. 297-305

Abstract

Stress produces analgesia and sucrose ingestion immediately relieves the stress in both the rat and human models, however the effect of sucrose feeding on chronic stress of repeated varying pain is not known. Adult male ratswere subjected to a stress regimen of restraint and various degrees of noxious stimuli given repeatedly during 58 h in six sessions with a rest of 32h. In a 4-h session, the rats were subjected to the stress of thermal noxious stimulation, pin prick and electrical stimulation of nociceptive afferents (six, one and nine times at intervals of S min) in addition to the restraint stress. The effect of this stress on their nociceptive responses was noted as hind paw lick latency, HPL; tail flick latency, TFL; threshold of tail flick, TF; vocalization during stimulus, SV and vocalization after discharge, VA. On the fourth day, the rats received sucrose solution (20 percent orally) ad libitum, which was withdrawn after session IV. During sessionIT-IV in pre-sucrose fed state, the TFL remained unaffected as compared tosession I, while the HPL decreased (18.53 +/- 4.96 s, 12.01 +/- 4.64 s in sessions I, VI respectively); and the thresholds for TF, SV and VA (0.34 +/- 0.16 and 0.71 +/- 0.32 mA in session I, VI respectively) progressively increased. After sucrose ingestion during sessions II-IV, the above-mentioneddecrease in HPL and increase in thresholds was not observed. However, theyappeared after discontinuation of sucrose during sessions V and VI. The results of our experiment suggest that exposure to our novel model of chronic(58 h) albeit intermittent stress of noxious stimuli and restraint produced an analgesic response in the threshold of TF, SV and VA, an hyperalgesic response in HPL and no effect in TFL; which were attenuated by ingesting a palatable sucrose solution ad libitum. Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 23:33:40