Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Alternatively activated antigen-presenting cells: Molecular repertoire, immune regulation, and healing
Autore:
Gratchev, A; Schledzewski, K; Guillot, P; Goerdt, S;
Indirizzi:
Univ Heidelberg, Med Ctr Mannheim, Dept Dermatol, D-6800 Mannheim, GermanyUniv Heidelberg Mannheim Germany D-6800 rmatol, D-6800 Mannheim, Germany
Titolo Testata:
SKIN PHARMACOLOGY AND APPLIED SKIN PHYSIOLOGY
fascicolo: 5, volume: 14, anno: 2001,
pagine: 272 - 279
SICI:
1422-2868(200109/10)14:5<272:AAACMR>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CD4(+) T-CELLS; MACROPHAGE INFLAMMATORY PROTEIN-1-ALPHA; COLONY-STIMULATING FACTOR; CC-CHEMOKINE (AMAC)-1; DENDRITIC CELLS; INTERFERON-GAMMA; HUMAN MONOCYTES; WEIGHT PROTEIN; MURINE MACROPHAGES; ENDOTHELIAL-CELLS;
Keywords:
antigen-presenting cell polarization; alternatively activated macrophages; immature myeloid dendritic cells; lymphoid dendritic cells; tolerance; downregulation of inflammation; induction of Th2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Goerdt, S Univ Klinikum, Klin Dermatol Venerol & Allergol, Klinikum Mannheim GmbH, Theodor Kutzer Ufer 1-3, D-68135 Mannheim, Germany Univ Klinikum Theodor Kutzer Ufer 1-3 Mannheim Germany D-68135
Citazione:
A. Gratchev et al., "Alternatively activated antigen-presenting cells: Molecular repertoire, immune regulation, and healing", SKIN PH APP, 14(5), 2001, pp. 272-279

Abstract

The Th1/Th2 paradigm has stimulated extensive research into the mechanismsunderlying T-cell polarization; alternative activation of antigen-presenting cells (APCs) has turned out to be the corresponding concept APC polarization. Macrophages (M phi) as well as dendritic cells (DCs) can undergo Th1-or Th2-like polarization; APC1 and APC2 thus acquire the capacity to drivethe development of naive T cells and the reactivation of resting T cells towards either a Th1 or a Th2 phenotype, respectively. Among polarized APC, effector macrophages are classically activated by mediators such as IFN-gamma, TNF-alpha or LPS (M phi1), while M phi2 are alternatively activated by IL-4, IL-10 or PGE(2). M phi2 exhibit a unique molecular repertoire including receptors of innate immunity with broad specificity for foreign antigen and anti-inflammatory cytokines such as IL-1 receptor antagonist and alternative macrophage activation-associated CC-chemokine (AMAC)-1. While DC1 arewell characterized, contradictory results have been obtained for DC2 that may either represent immature myeloid DCs or lymphoid DCs. Altogether, APC2have come to age; they mediate Th2 differentiation, tolerance induction, downregulation of inflammation and healing. Thus, APC2 represent a hitherto neglected, but indispensable major pathway of APC activation and function. Copyright (C) 2001 S. KargerAG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:44:10