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Titolo:
Anal intraepithelial neoplasia in HIV positive people
Autore:
Martin, F; Bower, M;
Indirizzi:
Chelsea & Westminster Hosp, Dept Oncol, London SW10 9NH, England Chelsea &Westminster Hosp London England SW10 9NH don SW10 9NH, England
Titolo Testata:
SEXUALLY TRANSMITTED INFECTIONS
fascicolo: 5, volume: 77, anno: 2001,
pagine: 327 - 331
SICI:
1368-4973(200110)77:5<327:AINIHP>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN PAPILLOMAVIRUS INFECTION; HUMAN-IMMUNODEFICIENCY-VIRUS; PERIANAL BOWENS-DISEASE; NEGATIVE HOMOSEXUAL MEN; BISEXUAL MEN; COST-EFFECTIVENESS; RISK-FACTORS; CANCER; LESIONS; ABNORMALITIES;
Keywords:
anal intraepithelial neoplasia; HIV; human papillomavirus;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Bower, M Chelsea & Westminster Hosp, Dept Oncol, Fulham Rd, London SW10 9NH, England Chelsea & Westminster Hosp Fulham Rd London England SW10 9NH and
Citazione:
F. Martin e M. Bower, "Anal intraepithelial neoplasia in HIV positive people", SEX TRANS I, 77(5), 2001, pp. 327-331

Abstract

Objective: To review the current literature on HIV associated anal intraepithelial neoplasia (AIN). Methods: A comprehensive Medline/Pubmed search was performed for the years1980-2001 (January) for articles pertaining to HIV associated anal intraepithelial neoplasia. From the MeSH terms "anal intraepithelial neoplasia" and "anal cancer" the following subheadings were used: HIV, homosexual men, HPV, Epidemiology, Etiology, Mortality, Diagnosis, Screening, Drug Therapy, Surgical Therapy, Radio Therapy, Risk factors, ASIL. The search was limitedto "human" for all searches. In the absence of enough "randomised controlled trials" the search was extended to clinical trials, reviews, and case reports. One analysis on cost effectiveness and two abstracts presented at 12th World AIDS Conference and 6th Conference on Retrovirus and OpportunisticInfections were included. The 44 publications referred to originate from the United Kingdom (9), the United States (26), and Denmark (5), with one each from Switzerland, Germany, Australia, and France. The Cochrane Database of systematic reviews yielded I I complete reviews for "anal cancer" and none for "anal intraepithelial neoplasia. " The textbook of AIDS-related cancers and their treatment was consulted. We also included our personal experience from the treatment of patients at the Chelsea and Westminster Hospital,one of the largest centres for the management of HIV disease in Europe. Conclusion: Routine anal cytological screening followed by appropriate management of AIN is an important issue for HIV infected patients. The naturalhistory of AIN has not been fully established and this prevents cliniciansfrom defining clear management protocols. There is early evidence that thebenefits of highly active antiretroviral therapy (HAART) in terms of restoring immune function and reducing opportunistic infections and some neoplasms may not extend to regression of AIN. Under these circumstances it might be predicted that AIN and subsequent progression to invasive anal cancer would rise as HAART prolongs the lives of seropositive people. However, routine anal cytological screening will surely have to await an effective provedintervention for AIN and this would seem to be a pressing clinical goal.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 19:41:11