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Titolo:
Estrogen receptor and breast cancer
Autore:
Sommer, S; Fuqua, SAW;
Indirizzi:
Baylor Coll Med, Breast Ctr, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 d, Breast Ctr, Houston, TX 77030 USA
Titolo Testata:
SEMINARS IN CANCER BIOLOGY
fascicolo: 5, volume: 11, anno: 2001,
pagine: 339 - 352
SICI:
1044-579X(200110)11:5<339:ERABC>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORMONE-RECEPTOR; STEROID-RECEPTORS; NUCLEAR RECEPTORS; ACTIVATION FUNCTION-1; PURE ANTIESTROGEN; N-COR; TRANSCRIPTIONAL ACTIVITY; GLUCOCORTICOID RECEPTOR; GENE-EXPRESSION; PARTIAL AGONIST;
Keywords:
antiestrogens; breast cancer; co-regulatory factors; estrogen receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
84
Recensione:
Indirizzi per estratti:
Indirizzo: Fuqua, SAW Baylor Coll Med, Breast Ctr, 1 Baylor Plaza, Houston, TX 77030 USA Baylor Coll Med 1 Baylor Plaza Houston TX USA 77030 X 77030 USA
Citazione:
S. Sommer e S.A.W. Fuqua, "Estrogen receptor and breast cancer", SEM CANC B, 11(5), 2001, pp. 339-352

Abstract

Breast cancer, the most common malignancy in women, was already known to be associated with the steroid hormone estrogen more than a century ago. Thediscovery of the estrogen receptor (ER) provided us not only with a powerful predictive and prognostic marker, but also an efficient target for the treatment of hormone-dependent breast cancer with antiestrogens. In this paper we will sketch the important role of ER in the development, progression,and treatment of the disease, which is complicated by the receptor's interaction with coregulatory proteins, its cross-talk with other signal transduction pathways, and its involvement in the development of antiestrogen resistance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 09:50:21