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Titolo:
CEREBROSPINAL-FLUID BROTH CULTURE ISOLATES - THEIR SIGNIFICANCE FOR ANTIBIOTIC-TREATMENT
Autore:
STURGIS CD; PETERSON LR; WARREN JR;
Indirizzi:
NORTHWESTERN UNIV,SCH MED,DEPT PATHOL,303 E CHICAGO AVE CHICAGO IL 60611 NORTHWESTERN UNIV,SCH MED,DEPT PATHOL CHICAGO IL 60611
Titolo Testata:
American journal of clinical pathology
fascicolo: 2, volume: 108, anno: 1997,
pagine: 217 - 221
SICI:
0002-9173(1997)108:2<217:CBCI-T>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPECIMENS;
Keywords:
CEREBROSPINAL FLUID [CSF]; BROTH CULTURE; DIAGNOSTIC MICROBIOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
7
Recensione:
Indirizzi per estratti:
Citazione:
C.D. Sturgis et al., "CEREBROSPINAL-FLUID BROTH CULTURE ISOLATES - THEIR SIGNIFICANCE FOR ANTIBIOTIC-TREATMENT", American journal of clinical pathology, 108(2), 1997, pp. 217-221

Abstract

Enriched broth medium is routinely used as a supplement for agar plate culture of cerebrospinal fluid (CSF). To assess the clinical utilityof broth cultures, 151 consecutive CSF bacterial and fungal isolates obtained from 91 patients were retrospectively reviewed for the effectof results on treatment. Treatment decisions associated with individual CSF specimens for which isolates were recovered from thioglycollatebroth only were compared with the treatment decisions associated withCSF specimens for which isolates were recovered by agar plate culture. Treatment was defined as initiation of or change in antimicrobial therapy based on the reporting of CSF culture isolates. Thirty-six (24%)of the 151 isolates were recovered in broth only. Three (8%) of these36 isolates (from 34 patients) resulted in treatment with antimicrobial agents; however, 2 of the 3 treated isolates (Candida tropicalis, Proteus mirabilis) were recovered from a second CSF specimen in agar plate culture within 24 hours. Thus, only a single isolate (3%; Staphylococcus epidermidis) was treated based solely on a positive broth culture result. In contrast, 60 (52%) of the 115 isolates recovered in agarplate culture from 23 (40%) of 57 patients were treated (staphylococci, 28; gram-negative bacilli, 14; Cryptococcus neoformans, 10; Streptococcus pneumoniae, 3; Streptococcus sanguis, 1; other, 4). We concludethat treatment with antimicrobial agents based on isolates recovered from CSF specimens in broth culture alone is infrequent and infer fromthe data that the use of CSF broth cultures contributes little to treatment decisions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 10:28:31