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Titolo:
Relationship between vascular endothelial growth factor and interleukin-6 in diabetic retinopathy
Autore:
Funatsu, H; Yamashita, H; Shimizu, E; Kojima, R; Hori, S;
Indirizzi:
Tokyo Womens Med Univ, Dept Ophthalmol, Ctr Diabet, Tokyo, Japan Tokyo Womens Med Univ Tokyo Japan Ophthalmol, Ctr Diabet, Tokyo, Japan Yamagata Univ, Sch Med, Dept Ophthalmol, Yamagata 99023, Japan Yamagata Univ Yamagata Japan 99023 ept Ophthalmol, Yamagata 99023, Japan
Titolo Testata:
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
fascicolo: 5, volume: 21, anno: 2001,
pagine: 469 - 477
SICI:
0275-004X(2001)21:5<469:RBVEGF>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
PIGMENT EPITHELIAL-CELLS; BLOOD-RETINAL BARRIER; ENDOTOXIN-INDUCED UVEITIS; PERMEABILITY FACTOR; PROLIFERATIVE VITREORETINOPATHY; NEOVASCULAR GLAUCOMA; OCULAR ANGIOGENESIS; GENE-EXPRESSION; AQUEOUS BARRIER; MESSENGER-RNA;
Keywords:
blood-retinal barrier; diabetic retinopathy; interleukin-6; neovascularization; vascular endothelial growth factor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Funatsu, H 8-1 Kawada Cho,Shinjuku Ku, Tokyo 1628666, Japan 8-1 Kawada Cho,Shinjuku Ku Tokyo Japan 1628666 1628666, Japan
Citazione:
H. Funatsu et al., "Relationship between vascular endothelial growth factor and interleukin-6 in diabetic retinopathy", RETINA, 21(5), 2001, pp. 469-477

Abstract

Purpose: To determine the relationship between the severity of diabetic retinopathy and the levels of interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) in aqueous humor and plasma. Methods: Forty-four eyes of 34 diabetic patients were studied. The concentrations of VEGF and IL-6 in plasma samples and in aqueous specimens obtained from the eyes during cataract surgery were measured by enzyme-linked immunosorbent assay. Results: Aqueous levels of VEGF and IL-6 were significantly correlated with the severity of diabetic retinopathy (rho = 0.793 and rho = 0.744, respectively). Vascular endothelial growth factor and IL-6 levels in aqueous humor were significantly correlated with the aqueous protein concentration (rho= 0.641 and rho = 0.646, respectively). The aqueous level of VEGF was significantly correlated with that of IL-6 (rho = 0.627). Aqueous levels of VEGF and IL-6 were also significantly correlated with the grade of fundus findings. Vascular endothelial growth factor and IL-6 concentrations were higher in the aqueous than in the plasma. Conclusion: The results of the current study suggest that there is a relationship between VEGF and IL-6 but the role of IL-6 in diabetic retinopathy is unclear and may warrant further investigation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 18:09:14