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Titolo: Tumor necrosis factor-alpha and muscle wasting: a cellular perspective
Autore: Reid, MB; Li, YP;
- Indirizzi:
- Baylor Coll Med, Pulm Sect, Houston, TX 77030 USA Baylor Coll Med HoustonTX USA 77030 ed, Pulm Sect, Houston, TX 77030 USA
- Titolo Testata:
- RESPIRATORY RESEARCH
fascicolo: 5,
volume: 2,
anno: 2001,
pagine: 269 - 272
- SICI:
- 1465-993X(2001)2:5<269:TNFAMW>2.0.ZU;2-2
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- OBSTRUCTIVE PULMONARY-DISEASE; RAT SKELETAL-MUSCLE; KAPPA-B ACTIVATION; TNF-ALPHA; PROTEIN BREAKDOWN; HEART-FAILURE; CACHEXIA; EXPRESSION; METABOLISM; RECEPTOR-1;
- Keywords:
- antioxidants; cachexia; cytokines; free radicals; skeletal muscle;
- Tipo documento:
- Editorial Material
- Natura:
- Periodico
- Settore Disciplinare:
- Clinical Medicine
- Citazioni:
- 27
- Recensione:
- Indirizzi per estratti:
- Indirizzo: Reid, MB Baylor Coll Med, Pulm Sect, Suite 520B,1 Baylor Plaza, Houston, TX 77030 USA Baylor Coll Med Suite 520B,1 Baylor Plaza Houston TX USA 77030 SA
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- Citazione:
- M.B. Reid e Y.P. Li, "Tumor necrosis factor-alpha and muscle wasting: a cellular perspective", RESPIR RES, 2(5), 2001, pp. 269-272
Abstract
Tumor necrosis factor-alpha (TNF-alpha) is a polypeptide cytokine that hasbeen associated with muscle wasting and weakness in inflammatory disease. Despite its potential importance in muscle pathology, the direct effects ofTNF-alpha on skeletal muscle have remained undefined until recently. Studies of cultured muscle cells indicate that TNF-alpha disrupts the differentiation process and can promote catabolism in mature cells. The latter response appears to be mediated by reactive oxygen species and nuclear factor-kappaB which upregulate ubiquitin/proteasome activity. This commentary outlines our current understanding of TNF-alpha effects on skeletal muscle and themechanism of TNF-alpha action.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/21 alle ore 16:45:55