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Titolo:
Tumor necrosis factor-alpha and muscle wasting: a cellular perspective
Autore:
Reid, MB; Li, YP;
Indirizzi:
Baylor Coll Med, Pulm Sect, Houston, TX 77030 USA Baylor Coll Med HoustonTX USA 77030 ed, Pulm Sect, Houston, TX 77030 USA
Titolo Testata:
RESPIRATORY RESEARCH
fascicolo: 5, volume: 2, anno: 2001,
pagine: 269 - 272
SICI:
1465-993X(2001)2:5<269:TNFAMW>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBSTRUCTIVE PULMONARY-DISEASE; RAT SKELETAL-MUSCLE; KAPPA-B ACTIVATION; TNF-ALPHA; PROTEIN BREAKDOWN; HEART-FAILURE; CACHEXIA; EXPRESSION; METABOLISM; RECEPTOR-1;
Keywords:
antioxidants; cachexia; cytokines; free radicals; skeletal muscle;
Tipo documento:
Editorial Material
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Reid, MB Baylor Coll Med, Pulm Sect, Suite 520B,1 Baylor Plaza, Houston, TX 77030 USA Baylor Coll Med Suite 520B,1 Baylor Plaza Houston TX USA 77030 SA
Citazione:
M.B. Reid e Y.P. Li, "Tumor necrosis factor-alpha and muscle wasting: a cellular perspective", RESPIR RES, 2(5), 2001, pp. 269-272

Abstract

Tumor necrosis factor-alpha (TNF-alpha) is a polypeptide cytokine that hasbeen associated with muscle wasting and weakness in inflammatory disease. Despite its potential importance in muscle pathology, the direct effects ofTNF-alpha on skeletal muscle have remained undefined until recently. Studies of cultured muscle cells indicate that TNF-alpha disrupts the differentiation process and can promote catabolism in mature cells. The latter response appears to be mediated by reactive oxygen species and nuclear factor-kappaB which upregulate ubiquitin/proteasome activity. This commentary outlines our current understanding of TNF-alpha effects on skeletal muscle and themechanism of TNF-alpha action.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 19:02:51