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Titolo:
Macrophages, neutrophils and tumour necrosis factor-alpha expression in bronchiectatic airways in vivo
Autore:
Zheng, L; Shum, IH; Tipoe, GL; Leung, R; Lam, WK; Ooi, GC; Tsang, KW;
Indirizzi:
Univ Hong Kong, Univ Dept Med, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong Hong Kong Hong Kong Peoples R China Kong, Peoples R China Univ Hong Kong, Univ Dept Anat, Hong Kong, Hong Kong, Peoples R China UnivHong Kong Hong Kong Hong Kong Peoples R China Kong, Peoples R China Univ Hong Kong, Univ Dept Diagnost Radiol, Hong Kong, Hong Kong, Peoples RChina Univ Hong Kong Hong Kong Hong Kong Peoples R China Kong, Peoples RChina
Titolo Testata:
RESPIRATORY MEDICINE
fascicolo: 10, volume: 95, anno: 2001,
pagine: 792 - 798
SICI:
0954-6111(200110)95:10<792:MNATNF>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYSTIC-FIBROSIS; CHRONIC-BRONCHITIS; T-LYMPHOCYTES; SPUTUM; CYTOKINES; LUNG; INFLAMMATION; MONOCYTES; INFECTION; ELASTASE;
Keywords:
bronchiectasis; neutrophils; macrophages; airway biopsy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Tsang, KW Univ Hong Kong, Queen Mary Hosp, Univ Dept Med, Pokfulam Rd, Hong Kong, Hong Kong, Peoples R China Univ Hong Kong Pokfulam Rd Hong Kong Hong Kong Peoples R China
Citazione:
L. Zheng et al., "Macrophages, neutrophils and tumour necrosis factor-alpha expression in bronchiectatic airways in vivo", RESP MED, 95(10), 2001, pp. 792-798

Abstract

Bronchiectasis is increasingly being recognized as an inflammatory condition of the airways in which pathological permanent dilation occurs. We have obtained endobronchial biopsies in 14 patients with stable bronchiectasis and 15 control subjects. Airway neutrophils, macrophages and tumour necrosisfactor-alpha (TNF alpha)-positive cells were stained with monoclonal antibodies and the densities of positive cells in the lamina propria were determined by using a computer image analyser. There was significantly higher neutrophil, macrophage and TNF alpha -positive cell densities in the lamina propria of bronchiectatic than control airways (P < 0.001, P < 0.001 and P=0.0002, respectively). Airway neutrophil density, in bronchiectasis but not in controls, correlated with TNF alpha -positive cell density (r=0.71, P=0.004). A significant correlation between airway macrophage and TNF alpha -positive cell densities was demonstrated in both control and bronchiectatic airways (r=0.63, P=0.016 and r=0.60, P=0.02 respectively). Neutrophil densitynegatively correlated with per cent forced vital capacity (FVC%) predictedamong patients with bronchiectasis (r=-0.53, P=0.04). Bronchiectasis patients who were regular sputum producers had a significantly higher macrophage, but not neutrophil density, than their counterparts (P=0.02 and P=0.48 respectively). Our original findings suggest that airway macrophages could contribute to neutrophil influx into airway walls through their production ofTNF alpha and therefore play an important role in the pathogenesis of bronchiectasis. (C) 2001 Harcourt Publishers Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 06:22:25