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Titolo:
CLINICAL-SIGNIFICANCE OF ENDOTHELIN IN CARDIOVASCULAR-DISEASE
Autore:
SCHIFFRIN EL; INTENGAN HD; THIBAULT G; TOUYZ RM;
Indirizzi:
CLIN RES INST MONTREAL,110 PINE AVE W MONTREAL PQ H2W 1R7 CANADA
Titolo Testata:
Current opinion in cardiology
fascicolo: 4, volume: 12, anno: 1997,
pagine: 354 - 367
SICI:
0268-4705(1997)12:4<354:COEIC>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RATS; INCREASED PLASMA ENDOTHELIN-1; ACUTE MYOCARDIAL-INFARCTION; ANEURYSMAL SUBARACHNOID HEMORRHAGE; CONGESTIVE-HEART-FAILURE; ACUTE ISCHEMIC STROKE; B RECEPTOR GENE; PULMONARY-HYPERTENSION; SYSTEMIC-SCLEROSIS; RAYNAUDS-PHENOMENON;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
148
Recensione:
Indirizzi per estratti:
Citazione:
E.L. Schiffrin et al., "CLINICAL-SIGNIFICANCE OF ENDOTHELIN IN CARDIOVASCULAR-DISEASE", Current opinion in cardiology, 12(4), 1997, pp. 354-367

Abstract

Endothelins are ubiquitously produced 21-amino-acid peptides that were discovered as an endothelial product and may play important roles incardiovascular physiology and pathophysiology. The main endothelin produced by the endothelium is endothelin-1. The vasoconstrictor role ofendothelins may participate in blood pressure elevation and vascular hypertrophy in salt-dependent models of hypertension (deoxycorticosterone acetate-salt hypertensive rats, spontaneously hypertensive rats treated with deoxycorticosterone acetate and salt, and Dahl salt-sensitive rats), and in stroke-prone spontaneously hypertensive rats. In humans, endothelins may play important roles in moderate to severe essential hypertension, and in the hypertension of African-Americans. Endothelins may be involved in cardiac hypertrophy, and there is increasing evidence of their participation in heart failure, in which acute endothelin antagonism in humans exerts beneficial effects. Endothelin expression is enhanced in smooth muscle cells migrating into the intima of arteries in atherosclerosis, suggesting a role in atherogenesis. Endothelin may participate as a vasoconstrictor in coronary artery disease, and as a contributor to intimal proliferation in restenosis after coronary angioplasty. in patients with myocardial infarction, cardiac production of endothelin is increased, particularly in those with cardiogenic shock There is a potential for participation of endothelins in vasospasm accompanying stroke or subarachnoid hemorrhage; in the latter, endothelin antagonism has shown beneficial effects in experimental models. in neonatal and in primary pulmonary hypertension, endothelin expression is enhanced, and in experimental models endothelin antagonism resulted in favorable responses. Systemic sclerosis is another, peripheral, form of vascular disease in which endothelin may play a role andin which endothelin antagonism may be an interesting therapeutic alternative. The pathophysiologic role of endothelins is becoming increasingly apparent in cardiovascular disease, generating interesting potential therapeutic targets for the use of endothelin antagonists or endothelin-converting enzyme inhibitors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 19:16:36