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Titolo:
Neuronal representations of stimulus associations develop in the temporal lobe during learning
Autore:
Messinger, A; Squire, LR; Zola, SM; Albright, TD;
Indirizzi:
Salk Inst Biol Studies, Howard Hughes Med Inst, La Jolla, CA 92037 USA Salk Inst Biol Studies La Jolla CA USA 92037 Inst, La Jolla, CA 92037 USA Salk Inst Biol Studies, Syst Neurobiol Lab, La Jolla, CA 92037 USA Salk Inst Biol Studies La Jolla CA USA 92037 Lab, La Jolla, CA 92037 USA Salk Inst Biol Studies, Sloan Ctr Theoret Neurobiol, La Jolla, CA 92037 USA Salk Inst Biol Studies La Jolla CA USA 92037 biol, La Jolla, CA 92037 USA Univ Calif San Diego, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 Diego, La Jolla, CA 92093 USA Vet Affairs Med Ctr, La Jolla, CA 92161 USA Vet Affairs Med Ctr La Jolla CA USA 92161 Med Ctr, La Jolla, CA 92161 USA
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 21, volume: 98, anno: 2001,
pagine: 12239 - 12244
SICI:
0027-8424(20011009)98:21<12239:NROSAD>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONDITIONAL OCULOMOTOR ASSOCIATIONS; SUPPLEMENTARY EYE FIELD; LONG-TERM-MEMORY; PRIMATE PREFRONTAL CORTEX; PERIRHINAL CORTEX; FRONTAL DISCONNECTION; INFEROTEMPORAL CORTEX; NEURAL ACTIVITY; VISUAL-CORTEX; RESPONSES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Albright, TD Salk Inst Biol Studies, Howard Hughes Med Inst, 10010 M Torrey Pines Rd, La Jolla, CA 92037 USA Salk Inst Biol Studies 10010 M Torrey Pines Rd La Jolla CA USA 92037
Citazione:
A. Messinger et al., "Neuronal representations of stimulus associations develop in the temporal lobe during learning", P NAS US, 98(21), 2001, pp. 12239-12244

Abstract

Visual stimuli that are frequently seen together become associated in long-term memory, such that the sight of one stimulus readily brings to mind the thought or image of the other. It has been hypothesized that acquisition of such long-term associative memories proceeds via the strengthening of connections between neurons representing the associated stimuli, such that a neuron initially responding only to one stimulus of an associated pair eventually comes to respond to both. Consistent with this hypothesis, studies have demonstrated that individual neurons in the primate inferior temporal cortex tend to exhibit similar responses to pairs of visual stimuli that have become behaviorally associated. In the present study, we investigated therole of these areas in the formation of conditional visual associations bymonitoring the responses of individual neurons during the learning of new stimulus pairs. We found that many neurons in both area TE and perirhinal cortex came to elicit more similar neuronal responses to paired stimuli as learning proceeded. Moreover, these neuronal response changes were learning-de pendent and proceeded with an average time course that paralleled learning. This experience-dependent plasticity of sensory representations in the cerebral cortex may underlie the learning of associations between objects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 01:46:24