Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
DNA microarray analysis of gene expression in endothelial cells in response to 24-h shear stress
Autore:
Chen, BPC; Li, YS; Zhao, YH; Chen, KD; Li, S; Lao, JM; Yuan, SL; Shyy, JYJ; Chien, S;
Indirizzi:
Univ Calif San Diego, Dept Bioengn, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 ioengn, La Jolla, CA 92093 USA Univ Calif San Diego, Whitaker Inst Biomed Engn, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 d Engn, La Jolla, CA 92093 USA Univ Calif Riverside, Div Biomed Sci, Riverside, CA 92521 USA Univ Calif Riverside Riverside CA USA 92521 Sci, Riverside, CA 92521 USA
Titolo Testata:
PHYSIOLOGICAL GENOMICS
fascicolo: 1, volume: 7, anno: 2001,
pagine: 55 - 63
SICI:
1094-8341(20011010)7:1<55:DMAOGE>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIGNAL-TRANSDUCTION; PHOSPHATIDYLINOSITOL 3-KINASE; NITRIC-OXIDE; MIGRATION; METALLOPROTEINASES; IDENTIFICATION; KINASE; ATHEROGENESIS; HYBRIDIZATION; ANGIOGENESIS;
Keywords:
DNA microarray; endothelial cells; gene expression; shear stress;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Chien, S Univ Calif San Diego, Dept Bioengn, Mail Code 0427,9500 Gilman Dr, La Jolla, CA 92093 USA Univ Calif San Diego Mail Code 0427,9500 Gilman DrLa Jolla CA USA 92093
Citazione:
B.P.C. Chen et al., "DNA microarray analysis of gene expression in endothelial cells in response to 24-h shear stress", PHYSIOL GEN, 7(1), 2001, pp. 55-63

Abstract

The recently developed DNA microarray technology provides a powerful and efficient tool to rapidly compare the differential expression of a large number of genes. Using the DNA microarray approach, we investigated gene expression profiles in cultured human aortic endothelial cells (HAECs) in response to 24 h of laminar shear stress at 12 dyn/cm(2). This relatively long-term shearing of cultured HAECs led to the modulation of the expression of a number of genes. Several genes related to inflammation and EC proliferationwere downregulated, suggesting that 24-h shearing may keep ECs in a relatively noninflammatory and nonproliferative state compared with static cells. Some genes were significantly upregulated by the 24-h shear stress; these includes genes involved in EC survival and angiogenesis (Tie2 and Flk-1) and vascular remodeling (matrix metalloproteinase 1). These results provide information on the profile of gene expression in shear-adapted ECs, which isthe case for the native ECs in the straight part of the aorta in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 04:45:25