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Titolo:
Cyclic ADP-ribose as a second messenger revisited from a new aspect of signal transduction from receptors to ADP-ribosyl cyclase
Autore:
Higashida, H; Hashii, M; Yokoyama, S; Hoshi, N; Chen, XL; Egorova, A; Noda, M; Zhang, JS;
Indirizzi:
Kanazawa Univ, Grad Sch Med, Dept Biophys Genet Mol Med & Bioinformat, Kanazawa, Ishikawa 9208640, Japan Kanazawa Univ Kanazawa Ishikawa Japan 9208640 wa, Ishikawa 9208640, Japan Krasnoyarsk State Med Acad, Dept Pathophysiol, Krasnoyarsk 660022, Russia Krasnoyarsk State Med Acad Krasnoyarsk Russia 660022 arsk 660022, Russia Kyushu Univ, Grad Sch Pharmaceut Sci, Lab Pathophysiol, Fukuoka 8128582, Japan Kyushu Univ Fukuoka Japan 8128582 b Pathophysiol, Fukuoka 8128582, Japan
Titolo Testata:
PHARMACOLOGY & THERAPEUTICS
fascicolo: 2-3, volume: 90, anno: 2001,
pagine: 283 - 296
SICI:
0163-7258(200105/06)90:2-3<283:CAAASM>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CA2+-INDUCED CA2+ RELEASE; SEA-URCHIN EGGS; NICOTINAMIDE-ADENINE-DINUCLEOTIDE; CARDIAC RYANODINE RECEPTOR; INTRACELLULAR CALCIUM-RELEASE; CEREBELLAR PURKINJE NEURONS; KCNQ1-4 POTASSIUM CHANNELS; RAT CORTICAL ASTROCYTES; FK506 BINDING-PROTEIN; CADP-RIBOSE;
Keywords:
Ca2+ signaling; ryanodine receptors; Ca2+-induced Ca2+ release; ADP-ribosyl cyclase; cyclic ADP-ribose hydrolase; CD38; neurotransmitter receptors;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
138
Recensione:
Indirizzi per estratti:
Indirizzo: Higashida, H Kanazawa Univ, Grad Sch Med, Dept Biophys Genet Mol Med & Bioinformat, 13-1 Takara Machi, Kanazawa, Ishikawa 9208640, Japan Kanazawa Univ 13-1 Takara Machi Kanazawa Ishikawa Japan 9208640
Citazione:
H. Higashida et al., "Cyclic ADP-ribose as a second messenger revisited from a new aspect of signal transduction from receptors to ADP-ribosyl cyclase", PHARM THERA, 90(2-3), 2001, pp. 283-296

Abstract

Cyclic ADP-ribose (cADPR), an endogenous modulator of ryanodine receptor Ca2+ -releasing channels, is found in various tissues. Cytosolic injection of cADPR induces an elevation of intracellular Ca2+ concentrations or potentiates Ca2+ increases. cADPR facilitates neurotransmitter or insulin releaseand modifies ionic currents. cADPR is synthesized by ADP-ribosyl cyclase and is metabolized by cADPR hydrolase. ADP-ribosyl cyclase activity is up-regulated by nitric oxide/cyclic GMP-dependent phosphorylation or receptor stimulation via G-proteins within membranes. These findings suggest that cADPR is a second messenger in cellular Ca2+ signaling. However, many intriguing issues remain to be addressed before this identity is confirmed. (C) 2001Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 20:05:45