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Titolo:
Cytochromes P450 of insects: the tip of the iceberg
Autore:
Scott, JG; Wen, ZM;
Indirizzi:
Cornell Univ, Dept Entomol, Ithaca, NY 14853 USA Cornell Univ Ithaca NY USA 14853 Univ, Dept Entomol, Ithaca, NY 14853 USA
Titolo Testata:
PEST MANAGEMENT SCIENCE
fascicolo: 10, volume: 57, anno: 2001,
pagine: 958 - 967
SICI:
1526-498X(200110)57:10<958:CPOITT>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUSCA-DOMESTICA L; IN-HOUSE FLY; FURANOCOUMARIN-INDUCIBLE CYTOCHROME-P450; PYRETHROID-RESISTANT MOSQUITO; CULEX-QUINQUEFASCIATUS SAY; MIXED-FUNCTION OXIDASES; HOST-PLANT UTILIZATION; MOLECULAR-CLONING; DROSOPHILA-MELANOGASTER; PERMETHRIN RESISTANCE;
Keywords:
insecticide resistance; plant-insect interactions; insect physiology; P450 monooxygenases; xenobiotic metabolism;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
116
Recensione:
Indirizzi per estratti:
Indirizzo: Scott, JG Cornell Univ, Dept Entomol, Comstock Hall, Ithaca, NY 14853 USA Cornell Univ Comstock Hall Ithaca NY USA 14853 aca, NY 14853 USA
Citazione:
J.G. Scott e Z.M. Wen, "Cytochromes P450 of insects: the tip of the iceberg", PEST MAN SC, 57(10), 2001, pp. 958-967

Abstract

The cytochrome P450-dependent monooxygenases are an extremely important metabolic system involved in the metabolism of endogenous compounds and xenobiotics. Collectively, P450 monooxygenases can metabolize numerous substrates and carry out multiple oxidative reactions. The large number: of substrates metabolized is due to the plethora of P450 isoforms and to the broad substrate specificity of some isoforms. Monooxygenases of insects have severalfunctional roles, including growth, development, feeding and protection against xenobiotics, including resistance to pesticides and tolerance to plant toxins. This review begins with background information about P450s and their evolution, followed by a discussion of the extraordinary diversity of insect P450s. Given the enormous interest in studying individual P450s, we then provide a synopsis of the different methods that have been used in their isolation and the substrates that are known to be metabolized. We conclude by summarizing the lessons we have learned from the study of individual insect P450s, including their roles in insecticide resistance, plant-insect interactions and insect physiology. However, these studies are just the 'tip of the iceberg'. Our knowledge continues to expand at a rapid pace, suggesting that the next decade will outpace the last in, terms of improving ourunderstanding of the cytochromes P450 of insects. (C) 2001 Society of Chemical Industry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:00:38