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Titolo:
Structure and diversity of insect nicotinic acetylcholine receptors
Autore:
Tomizawa, M; Casida, JE;
Indirizzi:
Univ Calif Berkeley, Environm Chem & Toxicol Lab, Dept Environm Sci Policy& Management, Berkeley, CA 94720 USA Univ Calif Berkeley Berkeley CA USA 94720 agement, Berkeley, CA 94720 USA
Titolo Testata:
PEST MANAGEMENT SCIENCE
fascicolo: 10, volume: 57, anno: 2001,
pagine: 914 - 922
SICI:
1526-498X(200110)57:10<914:SADOIN>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
APHID MYZUS-PERSICAE; CENTRAL-NERVOUS-SYSTEM; BUNGAROTOXIN BINDING COMPLEX; ALPHA-SUBUNIT; HIGH-AFFINITY; DROSOPHILA-MELANOGASTER; LIGAND-BINDING; HETEROLOGOUS EXPRESSION; PROTEIN; CLONING;
Keywords:
Drosophila; insects; Myzus; neonicotinoid insecticide; nicotinic acetylcholine receptor; nicotinic receptor subunit and subtype;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Casida, JE Univ Calif Berkeley, Environm Chem & Toxicol Lab, Dept EnvironmSci Policy& Management, Berkeley, CA 94720 USA Univ Calif Berkeley Berkeley CA USA 94720 rkeley, CA 94720 USA
Citazione:
M. Tomizawa e J.E. Casida, "Structure and diversity of insect nicotinic acetylcholine receptors", PEST MAN SC, 57(10), 2001, pp. 914-922

Abstract

The nicotinic acetylcholine receptor (nAChR) is an agonist-regulated ion-channel complex responsible for rapid neurotransmission. The vertebrate nAChR, assembled from five homologous subunits,, penetrates the synaptic membrane. Different subunit combinations lead to receptor subtypes with distinctive pharmacological profiles. In comparison with mammalian nAChRs, the insect receptor is, poorly understood relative to, functional architecture and diversity. Several genes for Drosophila, Locusta and Myzus encoding insect nAChR subunits have been identified, although the functional assembly and presence of different subtypes of these receptors are not defined. The insectnAChR is the primary target site for the neonicotinoid insecticides, thereby providing an incentive to explore its functional architecture with neonicotinoid radioligands, photoaffinity probes and affinity chromatography matrices. This review considers the current understanding of the structure anddiversity of insect nAChRs, based mainly on recent studies in molecular biology and protein biochemistry. (C) 2001 Society of Chemical Industry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/20 alle ore 20:26:15