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Titolo:
Persistent expression of cyclin D1 disrupts normal photoreceptor differentiation and retina development
Autore:
Skapek, SX; Lin, SCJ; Jablonski, MM; McKeller, RN; Tan, M; Hu, NP; Lee, EYHP;
Indirizzi:
St Jude Childrens Hosp, Dept Hematol Oncol, Memphis, TN 38105 USA St Jude Childrens Hosp Memphis TN USA 38105 Oncol, Memphis, TN 38105 USA Univ Texas, Hlth Sci Ctr, Dept Mol Med, San Antonio, TX 78245 USA Univ Texas San Antonio TX USA 78245 pt Mol Med, San Antonio, TX 78245 USA Univ Tennessee, Dept Ophthalmol, Memphis, TN 38163 USA Univ Tennessee Memphis TN USA 38163 ept Ophthalmol, Memphis, TN 38163 USA Univ Tennessee, Dept Anat & Neurobiol, Memphis, TN 38163 USA Univ Tennessee Memphis TN USA 38163 at & Neurobiol, Memphis, TN 38163 USA St Jude Childrens Hosp, Dept Biostat, Memphis, TN 38105 USA St Jude Childrens Hosp Memphis TN USA 38105 iostat, Memphis, TN 38105 USA
Titolo Testata:
ONCOGENE
fascicolo: 46, volume: 20, anno: 2001,
pagine: 6742 - 6751
SICI:
0950-9232(20011011)20:46<6742:PEOCDD>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETINOBLASTOMA PROTEIN; CELL-CYCLE; TARGETED DISRUPTION; ECTOPIC EXPRESSION; VERTEBRATE RETINA; MOUSE RETINA; MUTANT MICE; GENE; PATHWAY; DEATH;
Keywords:
cyclin D1; retina; RB; photoreceptors; retinoblastoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Skapek, SX St Jude Childrens Hosp, Dept Hematol Oncol, 332 N Lauderdale St, Memphis, TN 38105 USA St Jude Childrens Hosp 332 N Lauderdale St Memphis TN USA 38105
Citazione:
S.X. Skapek et al., "Persistent expression of cyclin D1 disrupts normal photoreceptor differentiation and retina development", ONCOGENE, 20(46), 2001, pp. 6742-6751

Abstract

The differentiation of neuronal cells in the developing mammalian retina is closely coupled to cell cycle arrest and proceeds in a highly organized manner. Cyclin D1, which regulates cell proliferation in many cells, also drives the proliferation of photoreceptor progenitors. In the mouse retina, cyclin D1 protein normally decreases as photoreceptors mature. To study the importance of the down-regulation of cyclin D1 during photoreceptor development, we generated a transgenic mouse in which cyclin D1 was persistently expressed in developing photoreceptor cells. We observed numerous abnormalities in both photoreceptors and other nonphotoreceptor cells in the retina of these transgenic mice. In particular, we observed delayed opsin expression in developing photoreceptors and alterations in their number and morphology in the mature retina. These alterations were accompanied by disorganization of the inner nuclear and plexiform layers. The expression of cyclin D1 caused excess photoreceptor cell proliferation and apoptosis. Loss of the p53 tumor suppressor gene decreased cyclin D1-induced apoptosis and led to microscopic hyperplasia in the retina. These findings are distinct from other mouse models in which the retinoblastoma gene pathway is disrupted and suggest that the IRBP-cyclin D1 mouse model may recapitulate an early step inthe development of retinoblastoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:27:58