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Titolo:
Overexpression of the thymosin beta-10 gene in human ovarian cancer cells disrupts F-actin stress fiber and leads to apoptosis
Autore:
Lee, SH; Zhang, W; Choi, JJ; Cho, Y; Lee, SH; Kim, JW; Hu, LM; Xu, J; Liu, JS; Lee, JH;
Indirizzi:
Sung Kyun Kwan Univ, Coll Med, Mol Therapy Res Ctr, Samsung Med Ctr,Kangnam Ku, Seoul 135701, South Korea Sung Kyun Kwan Univ Seoul South Korea 135701 , Seoul 135701, South Korea Sung Kyun Kwan Univ, Coll Med, Dept Obstet & Gynecol, Samsung Med Ctr,Kangnam Ku, Seoul 135701, South Korea Sung Kyun Kwan Univ Seoul South Korea 135701 , Seoul 135701, South Korea Univ Texas, MD Anderson Canc Ctr, Canc Genom Core Lab, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 anc Genom Core Lab, Houston, TX 77030 USA Univ Texas, MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 c Ctr, Dept Pathol, Houston, TX 77030 USA Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 & Lab Med, Philadelphia, PA 19104 USA
Titolo Testata:
ONCOGENE
fascicolo: 46, volume: 20, anno: 2001,
pagine: 6700 - 6706
SICI:
0950-9232(20011011)20:46<6700:OOTTBG>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA; BREAST-CANCER; EXPRESSION; PROSTATE; PROTEINS; P53; CARCINOMA; TUMORS; RAS;
Keywords:
thymosin beta-10; ovarian cancer; cDNA array;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, JH Sung Kyun Kwan Univ, Coll Med, Mol Therapy Res Ctr, Samsung Med Ctr,Kangnam Ku, 50 Ilwon Dong, Seoul 135701, South Korea Sung Kyun Kwan Univ 50 Ilwon Dong Seoul South Korea 135701 Korea
Citazione:
S.H. Lee et al., "Overexpression of the thymosin beta-10 gene in human ovarian cancer cells disrupts F-actin stress fiber and leads to apoptosis", ONCOGENE, 20(46), 2001, pp. 6700-6706

Abstract

To understand the molecular changes during ovarian cancer development, we profiled differentially expressed genes in five paired normal and cancerousovarian tissues. Among the genes that showed differential expression, thymosin beta -10 expression was decreased in four of five cancer tissues. The decreased level of expression was confirmed by Northern. To investigate thegene's functional role in ovarian cancers, we constructed an adenovirus vector expressing thymosin beta -10 and used it to infect ovarian cancer celllines PA-I and SKOV3. The infected cells showed disrupted F-actin stress fibers, markedly decreased cell growth, and a high rate of apoptosis. Thus, because loss of thymosin beta -10 expression may contribute to the development of a subset of ovarian cancers, restoration of thymosin beta -10 expression may be a new strategy for ovarian cancer treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 10:39:42