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Titolo:
T-1 relaxation times for viability evaluation of the engrafted and the native liver in a rat model of heterotopic auxiliary liver transplantation: a pilot study
Autore:
Fan, YD; Vanzieleghem, B; Achten, E; De Deene, Y; Defreyne, L; Praet, M; Van Huysse, J; Kunnen, M; de Hemptinne, B;
Indirizzi:
State Univ Ghent Hosp, Dept Surg, Div Surg Res, B-9000 Ghent, Belgium State Univ Ghent Hosp Ghent Belgium B-9000 rg Res, B-9000 Ghent, Belgium State Univ Ghent Hosp, Dept Radiol, B-9000 Ghent, Belgium State Univ GhentHosp Ghent Belgium B-9000 Radiol, B-9000 Ghent, Belgium State Univ Ghent Hosp, Dept Pathol, B-9000 Ghent, Belgium State Univ GhentHosp Ghent Belgium B-9000 Pathol, B-9000 Ghent, Belgium
Titolo Testata:
NMR IN BIOMEDICINE
fascicolo: 6, volume: 14, anno: 2001,
pagine: 350 - 359
SICI:
0952-3480(200110)14:6<350:TRTFVE>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
FULMINANT HEPATIC-FAILURE; GRAFT VIABILITY; PARAMETER;
Keywords:
heterotopic auxiliary liver transplantation; engrafted liver; native liver; post-transplant liver viability; magnetic resonance imaging; signal intensity; T-1 relaxation time; Wistar rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Fan, YD State Univ Ghent Hosp, Dept Surg, Div Surg Res, De Pintelaan 185, B-9000 Ghent, Belgium State Univ Ghent Hosp De Pintelaan 185 Ghent BelgiumB-9000 lgium
Citazione:
Y.D. Fan et al., "T-1 relaxation times for viability evaluation of the engrafted and the native liver in a rat model of heterotopic auxiliary liver transplantation: a pilot study", NMR BIOMED, 14(6), 2001, pp. 350-359

Abstract

Following a heterotopic auxiliary liver transplantation, commonly used measurements are either invasive or non-indicative of individual viability of the coexisting engrafted and native livers. Magnetic resonance imaging (MRI) was therefore tested for its potential to monitor the post-transplant hepatic viability in a rat model. Thirteen Wistar rats were systematically evaluated with MRI and serum biochemical liver parameters. Post-transplant complications and the causes of animal death were identified by autopsy and histo-pathological examinations. The data of the healthy survivors were compared with those of the rats that developed complications. On MRI, the hepatic complications could be depicted in the individual livers. A specific pattern of signal evolution was found in the livers of the healthy survivors: the mean T-1 relaxation times of the engrafted livers increased immediately after transplantation (476 +/- 64 ms, mean +/- standard deviation, pre-operative; 730 +/- 48 ms, week 1) and then declined steadily to a 3 month valueof 489 +/- 246 ms, while, following a transient first rise (476 +/- 64 ms,pre-operative; 589 +/- 28 ms, week 1), the mean T-1 value of the native livers increased again 4 weeks after surgery and reached a 3 month value of 859 +/- 43 rns. However, in the rats with various complications, the mean T-1 relaxation times of the engrafted livers continued to increase throughoutthe first post-operative month (760 +/- 48 ms, week 1; 922 +/- 76 ms, week4), while that of the native liver only varied mildly (546 +/- 25 ms, week1; 473 +/- 25 ms, week 4). After the first post-transplant week, the healthy engrafted livers could already be distinguished from those with complications by a significant decrease in T-1 relaxation times. These data suggestthat, besides demonstrating major complications, MRI may allow one to monitor the viability of each liver by analysing the relative signal intensity and T-1 relaxation times after a heterotopic auxiliary liver transplantation. Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:30:59