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Titolo:
Riluzole (2-amino-6-trifluoromethoxy benzothiazole) attenuates MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) neurotoxicity in mice
Autore:
Araki, T; Muramatsu, Y; Tanaka, K; Matsubara, M; Imai, Y;
Indirizzi:
Tohoku Univ, Grad Sch Pharmaceut Sci & Med, Dept Clin Pharmacol & Therapeut, Sendai, Miyagi 9808578, Japan Tohoku Univ Sendai Miyagi Japan 9808578 ut, Sendai, Miyagi 9808578, Japan
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1, volume: 312, anno: 2001,
pagine: 50 - 54
SICI:
0304-3940(20011012)312:1<50:R(BAM(>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL PARKINSONISM; DOPAMINE; MODEL; GLUTATHIONE; ANTAGONISM; ASTROCYTES; DISEASE; NEURONS; MONKEY;
Keywords:
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 2-amino-6-trifluoromethoxy benzothiazole; MK-801; dopamine; striatum; Parkinson's disease; immunohistochemistry; mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Araki, T Tohoku Univ, Grad Sch Pharmaceut Sci & Med, Dept Clin Pharmacol &Therapeut, Sendai, Miyagi 9808578, Japan Tohoku Univ Sendai Miyagi Japan 9808578 i, Miyagi 9808578, Japan
Citazione:
T. Araki et al., "Riluzole (2-amino-6-trifluoromethoxy benzothiazole) attenuates MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) neurotoxicity in mice", NEUROSCI L, 312(1), 2001, pp. 50-54

Abstract

The protective effects of 2-amino-6-trifluoromethoxy benzothiazole (riluzole), a Na channel blocker with antiglutamatergic activity were investigatedin the model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced depletion of dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) levels in mice. The mice were injected intraperitoneally (i.p.) with four administrations of MPTP (10 mg/kg) at 1 h intervals and then the brains were analyzed at 3 and 7 days after the treatments. Dopamine, DOPAC and HVA levels were significantly decreased in the striatum 3 days after MPTP treatments. Riluzole dose-dependently antagonized the MPTP-induceddecrease in dopamine, DOPAC and HVA levels in the striatum. MPTP treatmentalso caused a severe decrease in the amount of nigral tyrosine hydroxylaseprotein (TH) and microtuble-associated protein 2 (MAP 2) and produced a marked increase in the striatal glial fibrillary acidic protein (GFAP). Our immunohistochemical study with TH and MAP 2 staining showed that riluzole can protect against MPTP-induced neuronal damage in the substantia nigra. Furthermore, riluzole markedly increased the striatal GFAP-positive astrocytes3 days after MPTP treatments. These results suggest that riluzole is effective against MPTP-induced neurodegeneration of the nigrostriatal dopaminergic neuronal pathway. Our findings also may provide a rationale for the identification of astrocytes as a prominent target for the development of new therapies of Parkinson's disease. (C) 2001 Published by Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/06/19 alle ore 18:08:09