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Titolo:
Propofol activates vanilloid receptor channels expressed in human embryonic kidney 293 cells
Autore:
Tsutsumi, S; Tomioka, A; Sudo, M; Nakamura, A; Shirakura, K; Takagishi, K; Kohama, K;
Indirizzi:
Gunma Univ, Sch Med, Dept Pharmacol, Gunma 3718511, Japan Gunma Univ Gunma Japan 3718511 Med, Dept Pharmacol, Gunma 3718511, Japan Gunma Univ, Sch Med, Dept Orthoped Surg, Gunma 3718511, Japan Gunma Univ Gunma Japan 3718511 Dept Orthoped Surg, Gunma 3718511, Japan Gunma Univ, Sch Med, Dept Anesthesiol & Reanimatol, Gunma 3718511, Japan Gunma Univ Gunma Japan 3718511 hesiol & Reanimatol, Gunma 3718511, Japan
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1, volume: 312, anno: 2001,
pagine: 45 - 49
SICI:
0304-3940(20011012)312:1<45:PAVRCE>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAPSAICIN RECEPTOR; GLUTAMATE-RECEPTOR; ANESTHESIA; MECHANISMS; CURRENTS; NEURONS;
Keywords:
propofol; intravenous anesthetic; vanilloid receptor; capsaicin; human embryonic kidney 293 cell; calcium imaging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Tsutsumi, S Gunma Univ, Sch Med, Dept Pharmacol, Gunma 3718511, Japan Gunma Univ Gunma Japan 3718511 armacol, Gunma 3718511, Japan
Citazione:
S. Tsutsumi et al., "Propofol activates vanilloid receptor channels expressed in human embryonic kidney 293 cells", NEUROSCI L, 312(1), 2001, pp. 45-49

Abstract

Propofol (2,6-diisopropylphenol) is an intravenous anesthetic agent structurally unrelated to any other intravenous anesthetics. We examined the effect of propofol on a rat vanilloid receptor that was expressed in the human embryonic kidney (HEK) 293 cells by using calcium imaging method. Propofol caused a concentration-dependent increase in [Ca2+], in the HEK293 cells with the receptor. These responses were inhibited by removing extracellular calcium ions. The propofol-evoked increase in [Ca2+], in the HEK293 cells with the receptor was partially inhibited by capsazepine, a competitive antagonist of capsaicin. We conclude that propofol acts as an agonist for the receptor. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 05:28:27