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Titolo:
Effects of hypothermia on neonatal hypoxic-ischemic brain injury in the rat: phosphorylation of Akt, activation of caspase-3-like protease
Autore:
Tomimatsu, T; Fukuda, H; Endo, M; Watanabe, N; Mu, JW; Kohzuki, M; Fujii, E; Kanzaki, T; Murata, Y;
Indirizzi:
Osaka Univ, Fac Med, Dept Obstet & Gynecol, Suita, Osaka 5650871, Japan Osaka Univ Suita Osaka Japan 5650871 Gynecol, Suita, Osaka 5650871, Japan
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1, volume: 312, anno: 2001,
pagine: 21 - 24
SICI:
0304-3940(20011012)312:1<21:EOHONH>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHOSPHATIDYLINOSITOL 3-KINASE; NERVOUS-SYSTEM; KINASE AKT; CELL-DEATH; APOPTOSIS; SURVIVAL; NEURONS; DAMAGE; DNA; INHIBITOR;
Keywords:
apoptosis; caspase-3; Akt; PI3-kinese; immature brain; hypothermia; hypoxia-ischemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Tomimatsu, T Osaka Univ, Fac Med, Dept Obstet & Gynecol, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan Osaka Univ 2-2 Yamadaoka Suita Osaka Japan 5650871 871, Japan
Citazione:
T. Tomimatsu et al., "Effects of hypothermia on neonatal hypoxic-ischemic brain injury in the rat: phosphorylation of Akt, activation of caspase-3-like protease", NEUROSCI L, 312(1), 2001, pp. 21-24

Abstract

Neuroprotective mechanisms of hypothermia have not been clearly established especially in the immature brain. To investigate the effect of hypothermia on cell death and cell survival signal pathways, we studied caspase-3-like activity and activation of Akt in a rat model of neonatal hypoxic-ischemic (H-I) brain injury. Seven-day-old rats underwent a combination of left common carotid artery ligation and exposure to 8% O-2 for 1-h (n = 32). During recovery, the body temperature was reduced to 30 degreesC for 24 h in 16 animals, but was kept at 37 degreesC in 16 animals. Post-ischemic hypothermia was shown to diminish the caspase-3-like activity compared to normothermia at 6 and 24 h after H-I. Phospho-Akt was increased during the early reperfusion period after H-I in the normothermia group, but hypothermia rather decreased this enhanced phosphorylation of Akt following H-I. These resultsindicated that hypothermia may have some depressant effects on both cell death and cell survival signal pathways, and that Akt conceivably may not play a major role in the neuroprotective effect of hypothermia in the immature brain. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/10/20 alle ore 20:50:38