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Titolo:
Effects of the noncompetitive NMDA receptor antagonist MK-801 on classicaleyeblink conditioning in mice
Autore:
Takatsuki, K; Kawahara, S; Takehara, K; Kishimoto, Y; Kirino, Y;
Indirizzi:
Univ Tokyo, Sch Pharmaceut Sci, Neurobiol Lab, Tokyo 1130033, Japan Univ Tokyo Tokyo Japan 1130033 Sci, Neurobiol Lab, Tokyo 1130033, Japan
Titolo Testata:
NEUROPHARMACOLOGY
fascicolo: 5, volume: 41, anno: 2001,
pagine: 618 - 628
SICI:
0028-3908(200110)41:5<618:EOTNNR>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
NICTITATING-MEMBRANE RESPONSE; LONG-TERM POTENTIATION; RABBITS ORYCTOLAGUS-CUNICULUS; SYNAPTIC TRANSMISSION; BASOLATERAL AMYGDALA; IMPAIRS ACQUISITION; EPSILON-1 SUBUNIT; EYE-BLINK; RAT-BRAIN; HIPPOCAMPUS;
Keywords:
classical conditioning; eyeblink; hippocampus; cerebellum; dizocilpine; N-methyl-D-aspartate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Kawahara, S Univ Tokyo, Sch Pharmaceut Sci, Neurobiol Lab, Tokyo 1130033, Japan Univ Tokyo Tokyo Japan 1130033 iol Lab, Tokyo 1130033, Japan
Citazione:
K. Takatsuki et al., "Effects of the noncompetitive NMDA receptor antagonist MK-801 on classicaleyeblink conditioning in mice", NEUROPHARM, 41(5), 2001, pp. 618-628

Abstract

N-methyl-D-aspartate (NMDA) receptors are involved in synaptic plasticity and play a critical role in learning and memory. We investigated the effects of the noncompetitive NMDA receptor antagonist (+)MK-801 on classical eyeblink conditioning of mice, using various interstimulus intervals between the conditioned stimulus (CS) and unconditioned stimulus (US). A tone was used for the CS and a periorbital shock was used for the US. In the delay paradigm, in which the US coterminated with the CS or started immediately after CS offset, the effect of (+)MK-801 (0.1 mg/kg, i.p.) was a slight impairment in the acquisition of the conditioned response (CR). During subsequent CS-alone trials, the responses of (+)MK-801-injected mice were extinguishedas easily as those of saline-injected mice. In the trace paradigm, (+)MK-801 impaired acquisition of the CR with a trace interval of 250 ms more thanit did with a trace interval of 100 ms, and more than in the delay paradigm. (+)MK-801 injected after acquisition of 250-ms trace conditioning did not impair expression or extinction of the CR. These results suggest that NMDA receptors are involved in acquisition of the CR during longer trace interval conditioning more than during shorter trace interval conditioning or delay conditioning. and that their contribution to extinction is much smallerthan their contribution to acquisition in mouse eyeblink conditioning. (C)2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 23:05:58