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Titolo:
Widespread occurrence of argyrophilic glial inclusions in Parkinson's disease
Autore:
Hishikawa, N; Hashizume, Y; Yoshida, M; Sobue, G;
Indirizzi:
Nagoya Univ, Sch Med, Dept Neurol, Showa Ku, Nagoya, Aichi 4668550, Japan Nagoya Univ Nagoya Aichi Japan 4668550 a Ku, Nagoya, Aichi 4668550, Japan Aichi Med Univ, Inst Med Sci Aging, Nagakute, Aichi 48011, Japan Aichi MedUniv Nagakute Aichi Japan 48011 g, Nagakute, Aichi 48011, Japan
Titolo Testata:
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
fascicolo: 5, volume: 27, anno: 2001,
pagine: 362 - 372
SICI:
0305-1846(200110)27:5<362:WOOAGI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTIPLE-SYSTEM ATROPHY; LEWY-BODY-DISEASE; ALPHA-SYNUCLEIN IMMUNOREACTIVITY; PROGRESSIVE SUPRANUCLEAR PALSY; CYTOPLASMIC INCLUSIONS; NACP/ALPHA-SYNUCLEIN; GRAIN DISEASE; FIBRILLARY TANGLES; TAU-PROTEIN; OLIVOPONTOCEREBELLAR ATROPHY;
Keywords:
alpha-synuclein; argyrophilic glial inclusion; catecholaminergic neurones; Lewy body; Parkinson's disease;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Hishikawa, N Nagoya Univ, Sch Med, Dept Neurol, Showa Ku, 65 Tsurumai Cho,Nagoya, Aichi 4668550, Japan Nagoya Univ 65 Tsurumai Cho Nagoya Aichi Japan 4668550 Japan
Citazione:
N. Hishikawa et al., "Widespread occurrence of argyrophilic glial inclusions in Parkinson's disease", NEUROP AP N, 27(5), 2001, pp. 362-372

Abstract

Argyrophilic glial inclusions, which are immunohistochemically positive for alpha -synuclein but negative for tau protein, were examined in the brainof Parkinson's disease (PD) patients. Autopsied brains of 10 individuals who died from PD, of two incidental Lewy body disease cases and of five age-matched individuals whose deaths were caused by non-neurological diseases were studied, histopathologically, by Gallyas-Braak staining and, Immunohistochemically, with anti-alpha -synuclein antibody, anti-ubiquitin, and anti-tyrosine hydroxylase. All postmortem PD brains showed a significant number of argyrophilic glial inclusions, but no glial inclusions were found in control brains. The inclusions were found not only in the regions showing neuronal loss and gliosis, such as the substantia nigra, locus ceruleus and dorsal vagal nucleus, but also in regions without neuronal loss and gliosis, such as the cerebral cortex, cerebral white matter, striatum, globus pallidus, thalamus, cerebellum and spinal cord. The distribution and density of glial inclusions in PD brains varied from case to case but, in the cerebral cortex, the number of glial inclusions were fairly well correlated with the number of Lewy bodies. The distribution pattern of glial inclusions also showed a striking resemblance to that of catecholaminergic neurones and fibres. The abnormal accumulation of alpha -synuclein in glial cells was more widespread than neurone loss, and appears to be an important pathological feature of PD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 06:24:58