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Titolo:
Phosphorylated c-MYC expression in Alzheimer disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration
Autore:
Ferrer, I; Blanco, R; Carmona, M; Puig, B;
Indirizzi:
Univ Barcelona, Hosp Llobregat, Fac Med, Dept Biol Cellular & Anat Patol, Barcelona, Spain Univ Barcelona Barcelona Spain Cellular & Anat Patol, Barcelona, Spain Hosp Princeps & Espanya, Serv Anat Patol, Unitat Neuropatol, Barcelona, Spain Hosp Princeps & Espanya Barcelona Spain at Neuropatol, Barcelona, Spain Univ Barcelona, Banc Teixits Neurol, Hosp Clin, Barcelona, Spain Univ Barcelona Barcelona Spain xits Neurol, Hosp Clin, Barcelona, Spain
Titolo Testata:
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
fascicolo: 5, volume: 27, anno: 2001,
pagine: 343 - 351
SICI:
0305-1846(200110)27:5<343:PCEIAD>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
N-TERMINAL KINASE; CELL-CYCLE; SIGNAL-TRANSDUCTION; DNA-BINDING; GENE-EXPRESSION; MAP KINASE; OXIDATIVE STRESS; NERVOUS-SYSTEM; PROTEIN; APOPTOSIS;
Keywords:
Alzheimer disease; c-Myc; corticobasal degeneration; mitogen-activated protein kinases; neurofibrillary degeneration; Pick's disease; progressive supranuclear palsy; tau;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Ferrer, I Hosp Princeps & Espanya, Serv Anat Patol, Unitat Neuropatol, C Feixa Llarga SN, Hospitaler De Llobregat 08907, Spain Hosp Princeps & Espanya C Feixa Llarga SN Hospitaler De Llobregat Spain 08907
Citazione:
I. Ferrer et al., "Phosphorylated c-MYC expression in Alzheimer disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration", NEUROP AP N, 27(5), 2001, pp. 343-351

Abstract

Phosphorylated c-Myc (c-Myc-P) expression has been examined by immunohistochemistry, using an antibody that recognizes phosphorylated c-Myc at Thr58 and Ser62, in the brains of Alzheimer disease (AD), Pick's disease (PiD), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD) and age-matched control cases, as well as in human medulloblastomas and central neuroblastomas. Strong c-Myc-P immunoreactivity was seen in dystrophic neurites and neurones with neurofibrillary tangles in AD, and in neurones and glial cells bearing abnormal tau deposits in PiD, PSP and CBD. Previous studies have shown active Ras and increased mitogen-activated protein kinase (MAPK/ERK) expression in neurones and glial cells with abnormal tau depositionin AD and other tauopathies. Since MAPKs phosphorylate c-Myc at Thr58 and Ser62, these observations implicate the Ras/MAP kinase pathway in c-Myc phosphorylation and accumulation in AD and other tauopathies. Previous studieshave also shown activation of cell cycle associated proteins in neuronal death. The present results have shown colocalization of nuclear c-Myc-P and active, cleaved caspase-3, a major executioner of apoptosis, in medulloblastomas and central neuroblastomas, thus suggesting phosphorylated c-Myc expression in caspase-3-dependent apoptosis of tumour cells. However, no evidence of caspase-3 activation has been observed in neurones and glial cells with strong phosphorylated c-Myc immunoreactivity in AD, PiD, PSP and CBD. Therefore. it is not clear that the activation of the Ras/MAPK/c-Myc subprogramme leads to neuronal death in AD and other tauopathies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:24:02