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Titolo:
Some forms of cAMP-mediated long-lasting potentiation are associated with release of BDNF and nuclear translocation of phospho-MAP kinase
Autore:
Patterson, SL; Pittenger, C; Morozov, A; Martin, KC; Scanlin, H; Drake, C; Kandel, ER;
Indirizzi:
Columbia Univ Coll Phys & Surg, Howard Hughes Med Inst, New York, NY 10032USA Columbia Univ Coll Phys & Surg New York NY USA 10032 ew York, NY 10032USA Columbia Univ Coll Phys & Surg, Ctr Neurobiol & Behav, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA Univ Calif Los Angeles, Dept Psychiat, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Dept Biol Chem, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Cornell Univ, Weill Med Coll, Dept Neurol, Div Neurobiol, New York, NY 10021 USA Cornell Univ New York NY USA 10021 Div Neurobiol, New York, NY 10021 USA Cornell Univ, Weill Med Coll, Dept Neurosci, New York, NY 10021 USA Cornell Univ New York NY USA 10021 Dept Neurosci, New York, NY 10021 USA
Titolo Testata:
NEURON
fascicolo: 1, volume: 32, anno: 2001,
pagine: 123 - 140
SICI:
0896-6273(20011011)32:1<123:SFOCLP>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATED PROTEIN-KINASE; NERVE GROWTH-FACTOR; INDUCED SYNAPTIC POTENTIATION; CULTURED HIPPOCAMPAL-NEURONS; ACTIVITY-DEPENDENT RELEASE; TERM POTENTIATION; NEUROTROPHIC FACTOR; LATE-PHASE; RAT HIPPOCAMPUS; MEMORY STORAGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Kandel, ER Columbia Univ Coll Phys & Surg, Howard Hughes Med Inst, New York, NY 10032USA Columbia Univ Coll Phys & Surg New York NY USA 10032 10032USA
Citazione:
S.L. Patterson et al., "Some forms of cAMP-mediated long-lasting potentiation are associated with release of BDNF and nuclear translocation of phospho-MAP kinase", NEURON, 32(1), 2001, pp. 123-140

Abstract

Long-lasting forms of synaptic plasticity like the late phase of LTP (L-LTP) typically require an elevation of cAMP, the recruitment of the cAMP-dependent protein kinase (PKA), and ultimately the activation of transcription and translation; some forms also require brain-derived neurotrophic factor (BDNF). Both cAMP and BDNF can activate mitogen-activated protein kinase (MAPK/ERK), which also plays a role in LTP. However, little is known about the mechanisms whereby cAMP, BDNF, and MAPK interact. We find that increases in cAMP can rapidly activate the BDNF receptor TrkB and induce BDNF-dependent long-lasting potentiation at the Schaffer collateral-CA1 synapse in hippocampus. Surprisingly, in these BDNF-dependent forms of potentiation, whichare also MAPK dependent, TrkB activation is not critical for the activation of MAPK but instead appears to modulate the subcellular distribution and nuclear translocation of the activated MAPK.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 08:12:27