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Titolo:
PIP kinase 1 gamma is the major PI(4,5)P-2 synthesizing enzyme at the synapse
Autore:
Wenk, MR; Pellegrini, L; Klenchin, VA; Di Paolo, G; Chang, SH; Daniell, L; Arioka, M; Martin, TF; De Camilli, P;
Indirizzi:
Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06511 USA Yale Univ New Haven CT USA 06511 Hughes Med Inst, New Haven, CT 06511 USA Yale Univ, Sch Med, Dept Cell Biol, New Haven, CT 06511 USA Yale Univ NewHaven CT USA 06511 Dept Cell Biol, New Haven, CT 06511 USA Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 , Dept Biochem, Madison, WI 53706 USA Univ Tokyo, Dept Biotechnol, Bunkyo Ku, Tokyo 1138657, Japan Univ Tokyo Tokyo Japan 1138657 otechnol, Bunkyo Ku, Tokyo 1138657, Japan
Titolo Testata:
NEURON
fascicolo: 1, volume: 32, anno: 2001,
pagine: 79 - 88
SICI:
0896-6273(20011011)32:1<79:PK1GIT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLATHRIN-MEDIATED ENDOCYTOSIS; I PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASES; STIMULATION-DEPENDENT DEPHOSPHORYLATION; TERMINAL-SPECIFIC PHOSPHOPROTEIN; PLECKSTRIN HOMOLOGY DOMAIN; NERVE-TERMINALS; PLASMA-MEMBRANE; NEUROTRANSMITTER RELEASE; VESICLE EXOCYTOSIS; COATED VESICLES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
78
Recensione:
Indirizzi per estratti:
Indirizzo: De Camilli, P Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06511 USA Yale Univ New Haven CT USA 06511 t, New Haven, CT 06511 USA
Citazione:
M.R. Wenk et al., "PIP kinase 1 gamma is the major PI(4,5)P-2 synthesizing enzyme at the synapse", NEURON, 32(1), 2001, pp. 79-88

Abstract

Disruption of the presynaptically enriched polyphosphoinositide phosphatase synaptojanin 1 leads to an increase of clathrin-coated intermediates and of polymerized actin at endocytic zones of nerve terminals. These changes correlate with elevated levels of PI(4,5)P-2 in neurons. We report that phosphatidylinositol phosphate kinase type I gamma (PIPKI gamma), a major brainPI(4)P 5-kinase, is concentrated at synapses. Synaptojanin 1 and PIPKI gamma antagonize each other in the recruitment of clathrin coats to lipid membranes. Like synaptojanin 1 and other proteins involved in endocytosis, PIPKI gamma undergoes stimulation-dependent dephosphorylation. These results implicate PIPKI gamma in the synthesis of a PI(4,5)P-2 pool that acts as a positive regulator of clathrin coat recruitment and actin function at the synapse.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/01/21 alle ore 23:07:37