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Titolo:
Multiple sclerosis: infectious hypothesis
Autore:
Granieri, E; Casetta, I; Tola, MR; Ferrante, P;
Indirizzi:
Univ Ferrara, Dept Neurol, I-44100 Ferrara, Italy Univ Ferrara Ferrara Italy I-44100 , Dept Neurol, I-44100 Ferrara, Italy Univ Milan, IRCCS, Don C Gnocchi Fdn, Milan, Italy Univ Milan Milan Italy iv Milan, IRCCS, Don C Gnocchi Fdn, Milan, Italy
Titolo Testata:
NEUROLOGICAL SCIENCES
fascicolo: 2, volume: 22, anno: 2001,
pagine: 179 - 185
SICI:
1590-1874(200104)22:2<179:MSIH>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
VIRAL-INFECTIONS; DISEASE-ACTIVITY; EPIDEMIOLOGY; MS; ASSOCIATION; PREVALENCE; RELAPSES; ANTIGEN;
Keywords:
multiple sclerosis; infections; risk factors; epidemiology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Granieri, E Univ Ferrara, Dept Neurol, I-44100 Ferrara, Italy Univ Ferrara Ferrara Italy I-44100 l, I-44100 Ferrara, Italy
Citazione:
E. Granieri et al., "Multiple sclerosis: infectious hypothesis", NEUROL SCI, 22(2), 2001, pp. 179-185

Abstract

In the search for the etiology of multiple sclerosis (MS), consideration has been given in turn to infectious agents, to genetic markers, and more recently to a combination of genetic and environmental factors, but after over a. century of research, a definite conclusion has not been reached. The hypothesis that an infectious agent is responsible for triggering MS is perhaps one of neurology's most enduring notions. Interest in an infectious etiology has waxed and waned over the last two centuries since Pierre Marie first proposed that MS often starts as an infectious process. The possible role of infectious agents has been suggested by: the different geographic gradients in frequency among Caucasians; changes in prevalence due to migration, and the effect of age at migration; the suggestion of epidemics and clusters of cases in some small communities; and the remarkably low degree of concordance in monozygotic twins. The infectious hypothesis is strongly supported by the different temporal patterns of the disease in different geographic areas. Incidence rates have remained stable in some areas, but have changed over time in other regions. On the other hand, the hypothesis is hampered by the lack of evidence for a specific agent, and the weakness of the results of analytical studies that have tested the association between MS and previous infections. Despite these drawbacks, recent studies of a few select pathogens suggest that viral or bacterial infections or reactivations may trigger clinical exacerbations in relapsing-remitting MS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/12/19 alle ore 15:04:15