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Titolo:
Stress, glucocorticoids and the susceptibility to develop autoimmune disorders of the central nervous system
Autore:
Morale, C; Brouwer, J; Testa, N; Tirolo, C; Barden, N; Dijkstra, CD; Amor, S; Marchetti, B;
Indirizzi:
OASI, IRCCS, Neuropharmacol Unit, Inst Res & Care Mental Retardat & Brain Aging, Troina, EN, Italy OASI Troina EN Italy re Mental Retardat & Brain Aging, Troina, EN, Italy Vrije Univ Amsterdam, NL-1081 BT Amsterdam, Netherlands Vrije Univ Amsterdam Amsterdam Netherlands NL-1081 BT erdam, Netherlands Univ Laval, CHUL, Res Ctr, Quebec City, PQ G1V 4G2, Canada Univ Laval Quebec City PQ Canada G1V 4G2 Quebec City, PQ G1V 4G2, Canada Univ Laval, Dept Anat & Physiol, Quebec City, PQ G1V 4G2, Canada Univ Laval Quebec City PQ Canada G1V 4G2 Quebec City, PQ G1V 4G2, Canada Univ London Imperial Coll Sci & Technol, Sch Med, Div Neurosci, Dept Neuroinflammat, London, England Univ London Imperial Coll Sci & Technol LondonEngland London, England
Titolo Testata:
NEUROLOGICAL SCIENCES
fascicolo: 2, volume: 22, anno: 2001,
pagine: 159 - 162
SICI:
1590-1874(200104)22:2<159:SGATST>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
PITUITARY-ADRENOCORTICAL SYSTEM; TRANSGENIC MICE; DISRUPTION;
Keywords:
HPA axis; EAE; transgenic; glucocorticoid receptor; mRNA; stress; MOGs;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
5
Recensione:
Indirizzi per estratti:
Indirizzo: Marchetti, B Univ Sassari, Dept Pharmacol, Sch Med, I-07100 Sassari, ItalyUniv Sassari Sassari Italy I-07100 , I-07100 Sassari, Italy
Citazione:
C. Morale et al., "Stress, glucocorticoids and the susceptibility to develop autoimmune disorders of the central nervous system", NEUROL SCI, 22(2), 2001, pp. 159-162

Abstract

Alterations of the immunoendocrine circuit along the hypothalamic-pituitary-adrenocortical (HPA) axis in various autoimmune diseases have recently been observed, suggesting a modulatory role of this feedback regulation in the pathogenesis of autoimmune diseases. Susceptibility to experimental autoimmune encephalomyelitis (EAE) may be influenced by variations in the production of endogenous glucocorticoid hormones (GC). The adrenocortical response is central to recovery from EAE in the Lewis rat, as reflected by increased severity of the disease in adrenalectomized animals. The key role of GC in modifying the induction and progression of EAE is also emphasized by a reversal of corticoid-mediated effects through treatment with glucocorticoidreceptor (GR) antagonists. We studied the relationship between defective GR function and susceptibility to EAE in transgenic (Tg) mice expressing GR antisense RNA. EAE was induced with the encephalitogenic myelin oligodendrocyte peptide (pMOG 36-50) in wild type (Wt) and transgenic (Tg) female micebearing GR antisense RNA. pMOG 36-50 induced typical EAE in Wt mice but not in Tg mice. Histological examination of brains and spinal cords of Wt mice showed the presence of inflammation and/or demyelination, whereas in Tg mice neither were present. Although the mechanisms underlying the resistanceof Tg mice to EAE induction are not yet clarified, compensatory changes atdifferent levels of the HPA-immune axis in response to the potent immunogenic challenge are likely to participate in the observed effects. This work underlies the plasticity of the HPA-immune axis and suggests that pharmacological manipulation of neuroendocrine-immune networks may be a therapy of multiple sclerosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/10/20 alle ore 11:07:19