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Titolo:
Pathological abnormalities in the normal-appearing white matter in multiple sclerosis
Autore:
Allen, IV; McQuaid, S; Mirakhur, M; Nevin, G;
Indirizzi:
Queens Univ Belfast, Ctr Med Biol, Sch Biol & Biochem, Belfast BT9 7BL, Antrim, North Ireland Queens Univ Belfast Belfast Antrim North Ireland BT9 7BL m, North Ireland Royal Grp Hosp Trust, Reg Neuropathol Lab, Belfast, Antrim, North Ireland Royal Grp Hosp Trust Belfast Antrim North Ireland Antrim, North Ireland Univ Ulster, Sch Biomed Sci, Coleraine BT52 1SA, Londonderry, North Ireland Univ Ulster Coleraine Londonderry North Ireland BT52 1SA y, North Ireland
Titolo Testata:
NEUROLOGICAL SCIENCES
fascicolo: 2, volume: 22, anno: 2001,
pagine: 141 - 144
SICI:
1590-1874(200104)22:2<141:PAITNW>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVOUS-SYSTEM; MICROGLIA; LESIONS; BRAIN; INFLAMMATION; PLAQUES;
Keywords:
multiple sclerosis; NAWM; MRI; neuropathology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Allen, IV Queens Univ Belfast, Ctr Med Biol, Sch Biol & Biochem, Lisburn Rd, BelfastBT9 7BL, Antrim, North Ireland Queens Univ Belfast Lisburn Rd Belfast Antrim North Ireland BT9 7BL
Citazione:
I.V. Allen et al., "Pathological abnormalities in the normal-appearing white matter in multiple sclerosis", NEUROL SCI, 22(2), 2001, pp. 141-144

Abstract

In established cases of multiple sclerosis (MS), the normal-appearing white matter (NAWM), as defined for magnetic resonance imaging (MRI), is abnormal in the majority of cases. The clinical significance of these NAWM abnormalities is the subject of debate, but there is strong correlation with degree and progression of disability. New lesions form in NAWM before blood-brain barrier breakdown, as evidenced by gadolinium enhancement. The pathological basis of these neuroimaging abnormalities is largely unknown. Definitive pathological studies on the NAWM are few and are often based on small numbers of samples and of cases. Despite a variety of MS NAWM pathological studies, major research questions, of importance to our understanding of basicpathogenetic mechanisms and consequent rational therapies, remain unanswered. These relate to the frequency and extent of oligodendrocyte/myelin and axonal abnormalities in MS NAWM, and to the cellular basis of very early MSlesions detected by neuroimaging. In a pilot study of MS NAWM, microglial activation was demonstrated in 9 of 10 MS cases. We are currently testing the hypothesis that microglial activation, as defined by altered phenotype and HLA-DR positivity, will act as a marker for oligodendrocyte/myelin and axonal pathology in MS NAWM.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 19:14:16