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Titolo:
The prevalence of multiple sclerosis in the world: an update
Autore:
Rosati, G;
Indirizzi:
Univ Sassari, Inst Clin Neurol, I-07100 Sassari, Italy Univ Sassari Sassari Italy I-07100 t Clin Neurol, I-07100 Sassari, Italy
Titolo Testata:
NEUROLOGICAL SCIENCES
fascicolo: 2, volume: 22, anno: 2001,
pagine: 117 - 139
SICI:
1590-1874(200104)22:2<117:TPOMSI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-RISK AREA; GEOGRAPHIC-DISTRIBUTION; NORTHERN SPAIN; SANITARY DISTRICT; HEALTH-AUTHORITY; SOUTHERN EUROPE; GENETIC-FACTORS; WESTERN NORWAY; EAST-ANGLIA; NEW-ZEALAND;
Keywords:
multiple sclerosis; epidemiology; prevalence; world;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
177
Recensione:
Indirizzi per estratti:
Indirizzo: Rosati, G Univ Sassari, Inst Clin Neurol, Viale San Pietro 10, I-07100 Sassari, Italy Univ Sassari Viale San Pietro 10 Sassari Italy I-07100 i, Italy
Citazione:
G. Rosati, "The prevalence of multiple sclerosis in the world: an update", NEUROL SCI, 22(2), 2001, pp. 117-139

Abstract

The systematic study of multiple sclerosis (MS) in populations, started in1929 by Sydney Allison, now consists of over 400 publications dealing withthe prevalence of MS throughout the world. However, any attempt to redefine the pattern of geographical differences in MS frequency remains as difficult as ever. The comparison of prevalence studies carried out in different areas and times is made difficult by the variability in surveyed populationsizes, age structures, ethnic origins and composition, and the difficult quantification of numerators, especially regarding the recognition of benignand very early cases. Additionally, complete case ascertainment depends onaccess to medical care, local medical expertise, number of neurologists, accessibility and availability of new diagnostic procedures, the degree of public awareness about MS, and the investigators' zeal and resources. Critical examination of the more recent data on MS prevalence leads to some revisions of previously held concepts, the most interesting of which is the appreciation of the greater influence of genetic factors on disease acquisition. The rarity of MS among Samis, Turkmen, Uzbeks, Kazakhs, Kyrgyzis, native Siberians, North and South Amerindians, Chinese, Japanese, African blacks and New Zealand Maoris, as well as the high risk among Sardinians, Parsis and Palestinians, clearly indicate that the different susceptibilities of distinct racial and ethnic groups are an important determinant of the uneven geographic distribution of the disease. The updated distribution of MS in Europe, showing many exceptions to the previously described north-south gradient, requires more explanation than simply a prevalence-latitude relationship. Prevalence data imply that racial and ethnic differences are important in influencing the worldwide distribution of MS and that its geography mustbe interpreted in terms of the probable discontinuous distribution of genetic susceptibility alleles, which can however be modified by environment. Because the environmental and genetic determinants of geographic gradients are by no means mutually exclusive, the race versus place controversy is, tosome extent, a useless and sterile debate.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 11:35:18