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Titolo:
Complement in renal disease
Autore:
Charlesworth, JA; Peake, PW; Pussell, BA; Erlich, JH;
Indirizzi:
Prince Wales Hosp, Dept Nephrol, Randwick, NSW 2031, Australia Prince Wales Hosp Randwick NSW Australia 2031 ndwick, NSW 2031, Australia Univ New S Wales, Randwick, NSW, Australia Univ New S Wales Randwick NSW Australia Wales, Randwick, NSW, Australia
Titolo Testata:
NEPHROLOGY
fascicolo: 4, volume: 6, anno: 2001,
pagine: 145 - 154
SICI:
1320-5358(200111)6:4<145:CIRD>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYSTEMIC LUPUS-ERYTHEMATOSUS; RECEPTOR TYPE-1; C1Q DEFICIENCY; GLOMERULONEPHRITIS; EXPRESSION; ACTIVATION; GENERATION; ANTIBODY; CELLS; HEMODIALYSIS;
Keywords:
complement; deficiency and inhibition; glomerulonephritis; haemodialysis; renal disease;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Charlesworth, JA Prince Wales Hosp, Dept Nephrol, Level 3,High St Bldg,Barker St, Randwick,NSW 2031, Australia Prince Wales Hosp Level 3,High St Bldg,Barker St Randwick NSW Australia 2031
Citazione:
J.A. Charlesworth et al., "Complement in renal disease", NEPHROLOGY, 6(4), 2001, pp. 145-154

Abstract

The complement system consists of a series of plasma and membrane-based proteins that participate in a wide range of biological events. These may be advantageous or damaging to the host. Most complement-mediated effects involve sequential enzymatic activity or specific receptor-ligand interactions. Many tissues synthesize complement proteins, and substantial evidence suggests that these molecules contribute to local organ function. There is a long-established link between complement and various forms of renal disease, including glomerulonephritis (GN), tubulointerstitial inflammation and transplant rejection. Among the glomerulonephritides, significant changes in plasma complement concentration are observed most commonly in acute post-streptococcal disease, mesangiocapillary GN and lupus nephritis. The pattern ofabnormality may predominantly affect the classical or alternative pathway,and these changes are of diagnostic importance and, to a lesser extent, assist in monitoring disease activity. Complement deposition is demonstrable in a wide range of renal diseases, but convincing evidence of its involvement in the pathogenesis of specific diseases is quite limited. Complement reactivity also occurs during haemodialysis, and the generation of biologically active by-products has been demonstrated, to a variable extent, with different dialysis membranes. More recently, complement's involvement in the acute rejection of xenografts has been examined extensively, and attempts tomodify its participation in these processes have been partially successfulin experimental models. The long-term efficacy and practical value of therapeutic complement inhibition is currently under examination in a variety of human and experimental immunological disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 05:11:01