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Titolo:
Increased angiotensin-converting enzyme and type 1 angiotensin receptors in cortical vasculature and tubulointerstitium of chronically rejected humankidney allografts
Autore:
Ohishi, M; Ueda, M; Tanabe, S; Han, YS; Mendelsohn, FA; Zhuo, JL;
Indirizzi:
Henry Ford Hosp, Div Hypertens & Vasc Res, Detroit, MI 48202 USA Henry Ford Hosp Detroit MI USA 48202 ns & Vasc Res, Detroit, MI 48202 USA Osaka City Univ, Sch Med, Dept Geriatr Med, Osaka 545, Japan Osaka City Univ Osaka Japan 545 Med, Dept Geriatr Med, Osaka 545, Japan Osaka City Univ, Sch Med, Dept Pathol, Osaka 545, Japan Osaka City Univ Osaka Japan 545 , Sch Med, Dept Pathol, Osaka 545, Japan Osaka City Univ, Sch Med, Dept Urol, Osaka 545, Japan Osaka City Univ Osaka Japan 545 iv, Sch Med, Dept Urol, Osaka 545, Japan Univ Melbourne, Howard Florey Inst Expt Physiol & Med, Parkville, Vic 3052, Australia Univ Melbourne Parkville Vic Australia 3052 arkville, Vic 3052, Australia
Titolo Testata:
NEPHROLOGY
fascicolo: 5, volume: 6, anno: 2001,
pagine: 223 - 232
SICI:
1320-5358(2001)6:5<223:IAEAT1>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
UNILATERAL URETERAL OBSTRUCTION; RENAL INTERSTITIAL FIBROSIS; UP-REGULATION; EXPRESSION; LOCALIZATION; NEPHROPATHY; INJURY; RAT; TRANSPLANTATION; PROTEINURIA;
Keywords:
angiotensin II; angiotensin-converting enzyme; autoradiography; immunohistochemistry; renal allograft rejection; transplantation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Zhuo, JL Henry Ford Hosp, Div Hypertens & Vasc Res, 2799 Grand Blvd, Detroit, MI 48202 USA Henry Ford Hosp 2799 Grand Blvd Detroit MI USA 48202 MI 48202 USA
Citazione:
M. Ohishi et al., "Increased angiotensin-converting enzyme and type 1 angiotensin receptors in cortical vasculature and tubulointerstitium of chronically rejected humankidney allografts", NEPHROLOGY, 6(5), 2001, pp. 223-232

Abstract

Chronic rejection of human renal allografts after transplantation is characterized by interstitial infiltration, arteriosclerosis and glomerulosclerosis in the grafts. Apart from tissue HLA compatibility, angiotensin II (AII) may be implicated in accelerating the processes of chronic rejection. In the present study, the cellular distribution of angiotensin-converting enzyme (ACE) and type 1 AII (AT(1)) receptors was mapped and compared in non-rejected human kidneys (n = 8) and chronically rejected renal allografts (n =9) using complementary immunohistochemistry and quantitative in vitro autoradiography. Chronically rejected allografts showed typical histopathological characteristics of tissue rejection, including concentric intimal thickening of intrarenal arteries, extensive or focal glomerulosclerosis, tubularatrophy and severe tubulointerstitial fibrosis. In rejected allografts, total ACE binding in the cortex was decreased to 46% of that in non-rejected kidneys (P < 0.01), whereas AT(1) receptor binding in the glomeruli and theinner stripe of the outer medulla was maintained. However, ACE and AT(1) receptor binding were increased in the cortical tubulointerstitium of chronically rejected allografts. In non-rejected kidneys, strong ACE immunostaining occurred in proximal tubules and vascular endothelium, whereas AT(1) receptors occurred in vascular smooth muscle cells, as expected. In rejected allografts, intense ACE and AT(1) receptor immunostaining were detected not only in the same sites as those non-rejected kidneys, but also in cortical tubulointerstitium between atrophied tubules and surrounding the glomeruli. AT(1) receptors were markedly up-regulated in vascular smooth muscle cellsof thickened atherosclerotic vessels. These results provide novel morphological evidence that increased expression and/or altered distribution of ACEand AT(1) receptors in cortical tubulointerstitium and in the neointima ofintrarenal arteries may play an important role in the progression of chronic rejection of human renal allografts after transplantation.

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Documento generato il 22/01/20 alle ore 07:05:34