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Titolo:
A decade of CDK5
Autore:
Dhavan, R; Tsai, LH;
Indirizzi:
Harvard Univ, Sch Med, Howard Hughes Med Inst, Dept Pathol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Inst, Dept Pathol, Boston, MA 02115 USA
Titolo Testata:
NATURE REVIEWS MOLECULAR CELL BIOLOGY
fascicolo: 10, volume: 2, anno: 2001,
pagine: 749 - 759
SICI:
1471-0072(200110)2:10<749:ADOC>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLIN-DEPENDENT KINASE-5; DIRECTED PROTEIN-KINASE; NEURONAL CDC2-LIKE KINASE; BRAIN-SPECIFIC ACTIVATOR; PAIRED HELICAL FILAMENTS; TAU-PROTEIN; REGULATORY SUBUNIT; BOVINE BRAIN; NERVOUS-SYSTEM; BUDDING YEAST;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
129
Recensione:
Indirizzi per estratti:
Indirizzo: Tsai, LH Harvard Univ, Sch Med, Howard Hughes Med Inst, Dept Pathol, 200 Longwood Ave, Boston, MA 02115 USA Harvard Univ 200 Longwood Ave Boston MA USA 02115 n, MA 02115 USA
Citazione:
R. Dhavan e L.H. Tsai, "A decade of CDK5", NAT REV MOL, 2(10), 2001, pp. 749-759

Abstract

Since it was identified a decade ago, cyclin-dependent kinase 5 (CDK5) hasemerged as a crucial regulator of neuronal migration in the developing central nervous system. CDK5 phosphorylates a diverse list of substrates, implicating it in the regulation of a range of cellular processes - from adhesion and motility, to synaptic plasticity and drug addiction. Recent evidenceindicates that deregulation of this kinase is involved in the pathology ofneurodegenerative diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 21:05:03