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Titolo:
The INK4a/ARF network in tumour suppression
Autore:
Sherr, CJ;
Indirizzi:
St Jude Childrens Hosp, Howard Hughes Med Inst, Dept Tumor Cell Biol, Memphis, TN 38105 USA St Jude Childrens Hosp Memphis TN USA 38105 l Biol, Memphis, TN 38105 USA
Titolo Testata:
NATURE REVIEWS MOLECULAR CELL BIOLOGY
fascicolo: 10, volume: 2, anno: 2001,
pagine: 731 - 737
SICI:
1471-0072(200110)2:10<731:TINITS>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETINOBLASTOMA GENE FAMILY; CELL-CYCLE INHIBITION; S-PHASE ENTRY; P53-DEPENDENT APOPTOSIS; GROWTH SUPPRESSION; EPITHELIAL-CELLS; ONCOGENIC RAS; G(1) CONTROL; P53; P19(ARF);
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
77
Recensione:
Indirizzi per estratti:
Indirizzo: Sherr, CJ St Jude Childrens Hosp, Howard Hughes Med Inst, Dept Tumor Cell Biol, 332 N Lauderdale St, Memphis, TN 38105 USA St Jude Childrens Hosp 332N Lauderdale St Memphis TN USA 38105
Citazione:
C.J. Sherr, "The INK4a/ARF network in tumour suppression", NAT REV MOL, 2(10), 2001, pp. 731-737

Abstract

The retinoblastoma protein (RB) and p53 transcription factor are regulatedby two distinct proteins that are encoded by the INK4a/ARF locus. Genes encoding these four tumour suppressors are disabled, either in whole or in part, in most human cancers. A complex signalling network that interconnects the activities of RB and p53 monitors oncogenic stimuli to provide a cell-autonomous mode of tumour surveillance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 15:48:15