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Titolo:
The pso mutants of Saccharomyces cerevisiae comprise two groups: one deficient in DNA repair and another with altered mutagen metabolism
Autore:
Brendel, M; Henriques, JAP;
Indirizzi:
UFRGS, Ctr Biotechnol, Dept Biophys, BR-91507970 Porto Alegre, RS, Brazil UFRGS Porto Alegre RS Brazil BR-91507970 BC07970 Porto Alegre, RS, Brazil Univ Frankfurt, Inst Mikrobiol, D-60596 Frankfurt, Germany Univ FrankfurtFrankfurt Germany D-60596 iol, D-60596 Frankfurt, Germany
Titolo Testata:
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
fascicolo: 1, volume: 489, anno: 2001,
pagine: 79 - 96
SICI:
1383-5742(200110)489:1<79:TPMOSC>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERSTRAND CROSS-LINKS; NUCLEOTIDE EXCISION-REPAIR; 8-METHOXYPSORALEN PLUS UVA; CYTOCHROME-C-OXIDASE; YEAST RNASE MRP; POLYMERASE-ZETA; ERROR-PRONE; MOLECULAR-CLONING; CATALYTIC SUBUNIT; PRP19P-ASSOCIATED COMPLEX;
Keywords:
yeast; psoralen sensitivity; DNA repair; mutagenesis; cross-link repair; pre-mRNA splicing; ergosterol; cytochrome c oxidase;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
167
Recensione:
Indirizzi per estratti:
Indirizzo: Henriques, JAP UFRGS, Ctr Biotechnol, Dept Biophys, Av Bento Goncalves 9-500, BR-91507970Porto Alegre, RS, Brazil UFRGS Av Bento Goncalves 9-500 Porto Alegre RS Brazil BR-91507970 BC
Citazione:
M. Brendel e J.A.P. Henriques, "The pso mutants of Saccharomyces cerevisiae comprise two groups: one deficient in DNA repair and another with altered mutagen metabolism", MUT RES-R M, 489(1), 2001, pp. 79-96

Abstract

Yeast mutants that are sensitive to photoactivated psoralens, named pso mutants, were isolated and described more than 20 years ago. Nine genes responsible for the pso phenotypes were identified and seven of them cloned and molecularly characterized. Of the nine PSO genes of yeast seven apparently encode proteins involved in the repair of DNA lesions generated by photoinduced psoralens and by other mutagens, while two, PSO6 and PSO7, are responsible for structural elements of the membrane and for a functional respiratory chain, respectively. Of the seven proven or putative DNA repair genes six directly or indirectly control induced mutagenesis. Four of these PSO loci were found allelic to already known repair genes, whereas two, PSO2 and PSO4, represent new genes involved in DNA repair and in repair/pre-mRNA processing in S. cerevisiae. Gene PSO2 encodes a protein indispensable for repair of DNA interstrand cross-links that are produced by a variety of bi- andpoly-functional mutagens and that appears to be important for a likewise repair function in humans as well. (C) 2001 Published by Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 10:11:33