Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
From exposure to effect: a comparison of modeling approaches to chemical carcinogenesis
Autore:
van Leeuwen, IMM; Zonneveld, C;
Indirizzi:
Vrije Univ Amsterdam, Inst Ecol Sci, Fac Biol, Dept Theoret Biol, NL-1081 HV Amsterdam, Netherlands Vrije Univ Amsterdam Amsterdam Netherlands NL-1081 HV erdam, Netherlands
Titolo Testata:
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
fascicolo: 1, volume: 489, anno: 2001,
pagine: 17 - 45
SICI:
1383-5742(200110)489:1<17:FETEAC>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANCER RISK ASSESSMENT; STOCHASTIC 2-STAGE MODEL; JUNCTIONAL INTERCELLULAR COMMUNICATION; CUMULATIVE DISTRIBUTION FUNCTION; CLONAL EXPANSION MODEL; TUMOR-GROWTH; TUMORIGENIC POTENCY; MULTISTAGE MODEL; SOLID TUMOR; PHARMACODYNAMIC MODELS;
Keywords:
quantitative cancer risk assessment; tumor incidence; chemical carcinogen; mathematical model; dose-response relationship;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
160
Recensione:
Indirizzi per estratti:
Indirizzo: van Leeuwen, IMM Vrije Univ Amsterdam, Inst Ecol Sci, Fac Biol, Dept Theoret Biol, De Boelelaan 1087, NL-1081 HV Amsterdam, Netherlands Vrije Univ Amsterdam De Boelelaan 1087 Amsterdam Netherlands NL-1081 HV
Citazione:
I.M.M. van Leeuwen e C. Zonneveld, "From exposure to effect: a comparison of modeling approaches to chemical carcinogenesis", MUT RES-R M, 489(1), 2001, pp. 17-45

Abstract

Standardized long-term carcinogenicity tests aim to reveal the relationship between exposure to a chemical and occurrence of a carcinogenic response. The analysis of such tests may be facilitated by the use of mathematical models. To what extent current models actually achieve this purpose is difficult to evaluate. Various aspects of chemically induced carcinogenesis are treated by different modeling approaches, which proceed very much in isolation of each other. With this paper we aim to provide for the non-mathematician a comprehensive and critical overview of models dealing with processes involved in chemical carcinogenesis. We cover the entire process of carcinogenesis, from exposure to effect. We succinctly summarize the biology underlying the models and emphasize the relationship between model assumptions and model formulations. The use of mathematics is restricted as far as possible with some additional information relegated to boxes. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 20:22:23