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Titolo:
Fluoxetine enhances cell proliferation and prevents apoptosis in dentate gyrus of maternally separated rats
Autore:
Lee, HJ; Kim, JW; Yim, SV; Kim, MJ; Kim, SA; Kim, YJ; Kim, CJ; Chung, JH;
Indirizzi:
Kyung Hee Univ, Coll Med,Kohwang Med Res Inst, Dept Pharmacol, TongdaemoonKu, Seoul 130701, South Korea Kyung Hee Univ Seoul South Korea 130701 oonKu, Seoul 130701, South Korea Seoul Natl Mental Hosp, Kwangjin Ku, Seoul 143223, South Korea Seoul Natl Mental Hosp Seoul South Korea 143223 eoul 143223, South Korea Kangweon Natl Univ, Coll Med, Dept Pharmacol, Cheounchon 200701, Kangwon Do, South Korea Kangweon Natl Univ Cheounchon Kangwon Do South Korea 200701, South Korea
Titolo Testata:
MOLECULAR PSYCHIATRY
fascicolo: 6, volume: 6, anno: 2001,
pagine: 725 - 728
SICI:
1359-4184(200111)6:6<725:FECPAP>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROGENESIS; SEROTONIN; RESPONSES; STRESS;
Keywords:
fluoxetine; maternal separation; cell proliferation; apoptosis; dentate gyrus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Chung, JH Kyung Hee Univ, Coll Med,Kohwang Med Res Inst, Dept Pharmacol, TongdaemoonKu, 1 Hoegi Dong, Seoul 130701, South Korea Kyung Hee Univ 1 Hoegi Dong Seoul South Korea 130701 outh Korea
Citazione:
H.J. Lee et al., "Fluoxetine enhances cell proliferation and prevents apoptosis in dentate gyrus of maternally separated rats", MOL PSYCHI, 6(6), 2001, pp. 725-728

Abstract

The mother-infant relationship is an instinctive phenomenon, and loss of maternal care in early life influences neonatal development, behavior and physiologic responses.(1,2) Furthermore, the early loss may affect the vulnerability of the infant to neuropsychiatric disorders, such as childhood anxiety disorders, personality disorders and depression, over its lifespan.(3,4) Fluoxetine is prescribed worldwide for depression and is often used in the treatment of childhood mental problems related to maternal separation or loss of maternal care.(5,6) In the present study, fluoxetine was administrated to rats with maternal separation to determine its effects on neuronal development, in particular with respect to cell proliferation and apoptosis in the dentate gyrus of the hippocampus. Rat pups were separated from theirmothers and socially isolated on postnatal day 14 and were treated with fluoxetine (5 mg kg(-1)) and 5-bromo-2'-deoxyuridine (BrdU) (50 mg kg(-1)) for 7 days, after which immunohistochemistry and a terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) staining were carried out. In the pups with maternal separation treated with fluoxetine, the number of BrdU-positive cells was significantly increased and that of TUNEL-positive cells was significantly decreased in the dentate gyrus compared to pups with maternal separation that did not receive fluoxetine treatment. Thesefindings indicate that fluoxetine affects new cell proliferation and apoptosis, and we propose that fluoxetine may be useful in the treatment of maternal separation-related diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 14:34:29