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Titolo:
Evidence for co-release of noradrenaline and dopamine from noradrenergic neurons in the cerebral cortex
Autore:
Devoto, P; Flore, G; Pani, L; Gessa, G;
Indirizzi:
Univ Cagliari, Bb Brodie Dept Neurosci, I-09124 Cagliari, Italy Univ Cagliari Cagliari Italy I-09124 t Neurosci, I-09124 Cagliari, Italy CNR, Ctr Neuropharmacol, I-09124 Cagliari, Italy CNR Cagliari Italy I-09124 , Ctr Neuropharmacol, I-09124 Cagliari, Italy Neurosci Scarl, I-09124 Cagliari, Italy Neurosci Scarl Cagliari Italy I-09124 sci Scarl, I-09124 Cagliari, Italy
Titolo Testata:
MOLECULAR PSYCHIATRY
fascicolo: 6, volume: 6, anno: 2001,
pagine: 657 - 664
SICI:
1359-4184(200111)6:6<657:EFCONA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAL PREFRONTAL CORTEX; INCREASES EXTRACELLULAR DOPAMINE; LOCUS-COERULEUS; ANTIPSYCHOTIC-DRUGS; NUCLEUS-ACCUMBENS; BRAIN DOPAMINE; RAT-BRAIN; IN-VIVO; BLOCKADE; NOREPINEPHRINE;
Keywords:
microdialysis; clonidine; idazoxan; quinpirole; haloperidol; gamma-butyrolactone; cerebellum; prefrontal cortex; primary motor cortex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Devoto, P Univ Cagliari, Bb Brodie Dept Neurosci, Via Porcell 4, I-09124 Cagliari, Italy Univ Cagliari Via Porcell 4 Cagliari Italy I-09124 liari, Italy
Citazione:
P. Devoto et al., "Evidence for co-release of noradrenaline and dopamine from noradrenergic neurons in the cerebral cortex", MOL PSYCHI, 6(6), 2001, pp. 657-664

Abstract

The aim of this study was to determine whether extracellular dopamine (DA)in the prefrontal cortex (PFC) might originate other than from DA neurons,also from noradrenergic (NA) ones. To this aim, we compared the levels of DA and NA in the dialysates from the PFC, a cortical area innervated by NA and DA neurons, and cortices that receive NA but minor or no DA projectionssuch as the primary motor, the occipital-retrosplenial, and the cerebellarcortex. Moreover, the effect of alpha (2)-ligands and D-2-ligands that distinctly modify NA and DA neuronal activity on extracellular NA and DA in these areas was studied. Extracellular NA concentrations were found to be similar in the different cortices, as expected from the homogeneous NA innervation, however, unexpectedly, also DA concentrations in the PFC were not significantly different from those in the other cortices. The alpha (2)-adrenoceptor agonist clonidine, intraperitoneally (i.p.) injected or locally perfused into the PFC, reduced not only extracellular NA levels, as expected from its ability to inhibit NA neuron activity, but also markedly reduced extracellular DA levels. Conversely, the alpha (2)-adrenoceptor antagonist idazoxan, i.p. injected or locally perfused into the PFC, not only increased extracellular NA levels, in line with its ability to activate NA neuron activity, but also increased those of DA. Conversely, in contrast to its ability to inhibit DA neuronal activity, the D-2 receptor agonist quinpirole onlymodestly and transiently reduced extracellular DA levels, while gamma -butyrolactone failed to modify DA levels in the PFC; conversely, haloperidol, at variance from its ability to activate DA neurons, failed to significantly modify extracellular DA levels in the PFC. Both haloperidol and quinpirole were totally ineffective after local perfusion into the PFC. Systemicallyinjected or locally perfused, clonidine and idazoxan also modified both DAand NA concentrations in dialysates from primary motor, occipital-retrosplenial and cerebellar cortices as observed in the PFC. Finally, i.p. injected or locally perfused, clonidine reduced and idazoxan increased extracellular NA levels in the caudate nucleus, but neither alpha (2)-ligand significantly modified extracellular DA levels. Our results suggest that extracellular DA in the PFC, as well as in the other cortices, may depend on NA ratherthan DA innervation and activity. They suggest that dialysate DA reflects the amine released from NA neurons as well, where DA acts not only as NA precursor but also as co-transmitter. The co-release of NA and DA seems to becontrolled by alpha (2)-receptors located on NA nerve terminals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:21:51