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Titolo:
Schizophrenia and viral infection during neurodevelopment: a focus on mechanisms
Autore:
Pearce, BD;
Indirizzi:
Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 ychiat & Behav Sci, Atlanta, GA 30322 USA
Titolo Testata:
MOLECULAR PSYCHIATRY
fascicolo: 6, volume: 6, anno: 2001,
pagine: 634 - 646
SICI:
1359-4184(200111)6:6<634:SAVIDN>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
BORNA-DISEASE-VIRUS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MONOZYGOTIC TWINS DISCORDANT; BIPOLAR AFFECTIVE-DISORDER; MINOR PHYSICAL ANOMALIES; GUILLAIN-BARRE-SYNDROME; CELL-ADHESION MOLECULE; GABA UPTAKE SITES; MAGNETIC-RESONANCE; ADULT SCHIZOPHRENIA;
Keywords:
GABA; glutamic acid; hippocampus; autoimmunity; blood-brain barrier; pregnancy complications; virus diseases;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
182
Recensione:
Indirizzi per estratti:
Indirizzo: Pearce, BD Emory Univ, Sch Med, Dept Psychiat & Behav Sci, 1639 Pierce Dr WMB-4000, Atlanta, GA 30322 USA Emory Univ 1639 Pierce Dr WMB-4000 Atlanta GA USA 30322 322 USA
Citazione:
B.D. Pearce, "Schizophrenia and viral infection during neurodevelopment: a focus on mechanisms", MOL PSYCHI, 6(6), 2001, pp. 634-646

Abstract

The task of defining schizophrenia pathogenesis has fascinated and frustrated researchers for nearly a century. In recent years, unprecedented advances from diverse fields of study have given credence to, both, viral. and developmental theories. This review considers possible mechanisms by which; viral and developmental processes may interact to engender schizophrenia. Many of the current, controversies in schizophrenia pathogenesis are reviewedin light of the viral hypothesis, including. epidemiological findings and the role of a genetic diathesis, phenotype heterogeneity,, abnormalities inexcitatory and inhibitory neurotransmitter systems, anomalous cerebral latereralization, and static vs progressive disease. The importance of animal models, in elucidating the impact of viral infections on developing neuronsis illustrated by recent studies in which: neonatal rats are infected withlymphocytic choriomeningitis virus in order to examine alterations in hippocampal circuitry. Finally, consideration is: given to a new hypothesis that some cases of schizophrenia could be instigated by a viral infection thatdisrupts developing Inhibitory circuits, consequently unleashing glutamatergic neurotransmission leading to selective excitotoxicity, and a degenerative disease course.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 13:28:59