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Titolo:
The other, forgotten genome: mitochondrial DNA and mental disorders
Autore:
Kato, T;
Indirizzi:
RIKEN, Brain Sci Inst, Lab Mol Dynam Mental Disorders, Wako, Saitama 3510198, Japan RIKEN Wako Saitama Japan 3510198 Disorders, Wako, Saitama 3510198, Japan
Titolo Testata:
MOLECULAR PSYCHIATRY
fascicolo: 6, volume: 6, anno: 2001,
pagine: 625 - 633
SICI:
1359-4184(200111)6:6<625:TOFGMD>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIPOLAR AFFECTIVE-DISORDER; MAGNETIC-RESONANCE SPECTROSCOPY; ALZHEIMERS-DISEASE PATIENTS; BRAIN ENERGY-METABOLISM; C-OXIDASE ACTIVITY; DIABETES-MELLITUS; WOLFRAM-SYNDROME; SCHIZOPHRENIC-PATIENTS; CALCIUM HOMEOSTASIS; POINT MUTATIONS;
Keywords:
bipolar disorder; mitochondria; molecular genetics; electron transport chain; postmortem brain; schizophrenia;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
124
Recensione:
Indirizzi per estratti:
Indirizzo: Kato, T RIKEN, Brain Sci Inst, Lab Mol Dynam Mental Disorders, Hirosawa 2-1, Wako,Saitama 3510198, Japan RIKEN Hirosawa 2-1 Wako Saitama Japan 3510198 itama 3510198, Japan
Citazione:
T. Kato, "The other, forgotten genome: mitochondrial DNA and mental disorders", MOL PSYCHI, 6(6), 2001, pp. 625-633

Abstract

This paper summarizes recent research on mitochondrial DNA (mtDNA)-which might be described as the 'other, forgotten genome'. Recent studies suggest the possible pathophysiological significance of mtDNA in schizophrenia and neurodegenerative and mood disorders. Decreased activity of the mitochondrial electron transport chain has been implicated in both Parkinson's and Alzheimer's disease and while age-related accumulation of mtDNA deletions has been suggested as a possible cause, there is no concrete evidence that particular mtDNA polymorphisms are responsible. In schizophrenia, the activity and/or mRNA expression of complex IV are involved, but the direction of thealteration is not the same and there is no evidence linking schizophrenia with mtDNA. In bipolar disorder, there is some evidence of parent-of-origineffects and association with mtDNA polymorphisms but further investigationis needed to elucidate the role of mtDNA in mental disorders.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/12/19 alle ore 11:26:56