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Titolo:
Eating behavior in anorexia nervosa - an excess of both orexigenic and anorexigenic signalling?
Autore:
Inui, A;
Indirizzi:
Kobe Univ, Sch Med, Dept Internal Med 2, Chuo Ku, Kobe, Hyogo 6500017, Japan Kobe Univ Kobe Hyogo Japan 6500017 2, Chuo Ku, Kobe, Hyogo 6500017, Japan
Titolo Testata:
MOLECULAR PSYCHIATRY
fascicolo: 6, volume: 6, anno: 2001,
pagine: 620 - 624
SICI:
1359-4184(200111)6:6<620:EBIAN->2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
BODY-WEIGHT REGULATION; BULIMIA-NERVOSA; FEEDING-BEHAVIOR; NEUROPEPTIDE-Y; FOOD-INTAKE; RESPONSES; SEROTONIN; LEPTIN; CHOLECYSTOKININ; DISORDERS;
Keywords:
anorexia nervosa; orexigenic signal; anorexigenic signal; leptin; corticotropin-releasing factor; neuropeptide Y; starvation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Inui, A Kobe Univ, Sch Med, Dept Internal Med 2, Chuo Ku, Kobe, Hyogo 6500017, Japan Kobe Univ Kobe Hyogo Japan 6500017 Ku, Kobe, Hyogo 6500017, Japan
Citazione:
A. Inui, "Eating behavior in anorexia nervosa - an excess of both orexigenic and anorexigenic signalling?", MOL PSYCHI, 6(6), 2001, pp. 620-624

Abstract

Anorexia nervosa (AN) is a disorder characterized by abnormal eating behavior, weight regulation, and disturbances in attitudes and perceptions toward body weight and shape. Although progress has been made, in the treatment of AN, a substantial portion of patients have a limited response to treatment. Multiple endocrine and! metabolic changes occur after prolonged starvation, conserving energy and protein. A number of the endocrine findings in patients with AN may be secondary to adaptive mechanisms. However, AN differs from simple starvation in that excess of both feeding-stimulatory (orexigenic) and feeding-inhibitory (anorexigenic) signalling is characteristic, producing the 'mixed' signal about satiety and desire to feed. This leads to, a failure of the adaptive feeding response that is initiated by a decrease in leptin, an adiposity signal from fat tissue.,, and the resultant increase and decrease of orexigenic and anorexigenic signalling,, respectively. The hypothesis of unbalanced shift of feeding-regulatory circuitry places anorexigenic corticotropin-releasing factor and orexigenic neuropeptide Y inthe final common neurobiological substrate for AN. Therapeutic intervention using such receptor antagonists, may lead to more successful and targetedpsychopharmacological treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 12:07:11