Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Interleukin-10 is produced by human uterine natural killer cells but does not affect their production of interferon-gamma
Autore:
Vigano, P; Gaffuri, B; Somigliana, E; Infantino, M; Vignali, M; Di Blasio, AM;
Indirizzi:
Ist Auxol Italiano, Mol Biol Lab, I-20135 Milan, Italy Ist Auxol ItalianoMilan Italy I-20135 ol Biol Lab, I-20135 Milan, Italy Univ Milan, Sch Med, Dept Obstet & Gynecol 2, Milan, Italy Univ Milan Milan Italy , Sch Med, Dept Obstet & Gynecol 2, Milan, Italy
Titolo Testata:
MOLECULAR HUMAN REPRODUCTION
fascicolo: 10, volume: 7, anno: 2001,
pagine: 971 - 977
SICI:
1360-9947(200110)7:10<971:IIPBHU>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECURRENT SPONTANEOUS-ABORTION; LARGE GRANULAR LYMPHOCYTES; T-HELPER CYTOKINES; IFN-GAMMA; IL-10 PRODUCTION; HUMAN PLACENTA; CUTTING EDGE; NK CELLS; PREGNANCY; WOMEN;
Keywords:
immune response; IFN-gamma; IL-10; pregnancy; uterine NK cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Di Blasio, AM Ist Auxol Italiano, Mol Biol Lab, Vle Monte Nero 32, I-20135Milan, Italy Ist Auxol Italiano Vle Monte Nero 32 Milan Italy I-20135 ly
Citazione:
P. Vigano et al., "Interleukin-10 is produced by human uterine natural killer cells but does not affect their production of interferon-gamma", MOL HUM REP, 7(10), 2001, pp. 971-977

Abstract

A predominance of T helper (Th)2-type cytokines and a weakening of Th1 responses seem to be critical for the maintenance of a successful gestation. Among Th2-type cytokines, interleukin (IL)-10 is produced by human cytotrophoblasts and defects in this production result in specific pathological conditions of pregnancy. The current opinion is that IL-10 serves to protect the fetus from a harmful maternal immune response. However, production of thecytokine and its direct effect on uterine natural killer (uNK) cells, which represent the predominant lymphocyte population infiltrating the pregnantendometrium, are largely unknown. Thus, to shed light on the cytokine network at the maternal-fetal barrier during early pregnancy, we investigated the IL-10 system in uNK cells. We showed that uNK cells express the mRNA transcripts for IL-10 and IL-10 receptor. Production of IL-10 by the uNK cellswas enhanced by both IL-2 and IL-12. Treatment with IL-10 alone enhanced uNK cell cytotoxic activity. In contrast, the cytokine did not modify the basal or stimulated production of interferon (IFN)-gamma by uNK. Thus, IL-10 does not act as a direct antagonist of uNK cell function and activation. However, IL-10 produced by uNK cells in response to IL-12 and IL-2 may still have a feedback inhibitory effect on the production of deleterious cytokines within the uterine microenvironment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 18:36:41