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Titolo:
Influences of adenosine on the fetus and newborn
Autore:
Rivkees, SA; Zhao, ZY; Porter, G; Turner, C;
Indirizzi:
Yale Univ, Sch Med, Dept Pediat, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 ed, Dept Pediat, New Haven, CT 06520 USA Yale Univ, Sch Med, Interdept Neurosci Program, New Haven, CT 06520 USA Yale Univ New Haven CT USA 06520 eurosci Program, New Haven, CT 06520 USA
Titolo Testata:
MOLECULAR GENETICS AND METABOLISM
fascicolo: 1-2, volume: 74, anno: 2001,
pagine: 160 - 171
SICI:
1096-7192(200109/10)74:1-2<160:IOAOTF>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULAR-CLONING; RAT-BRAIN; RECEPTOR EXPRESSION; A(3) RECEPTORS; BINDING-SITE; FETAL SHEEP; A(1); RELEASE; INJURY; AUTORADIOGRAPHY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Rivkees, SA Yale Pediat, PO 208081, New Haven, CT 06520 USA Yale Pediat PO208081 New Haven CT USA 06520 ven, CT 06520 USA
Citazione:
S.A. Rivkees et al., "Influences of adenosine on the fetus and newborn", MOL GEN MET, 74(1-2), 2001, pp. 160-171

Abstract

Few signaling molecules have the potential to influence the developing mammal as the nucleoside adenosine. In contrast to most neurotransmitters, adenosine is released by all cells and is present in all tissues. The adenosinergic system is therefore not dependent on the presence of mature synaptic structures or an intact autonomic nervous system for its release. However, similar to other signaling molecules, adenosine levels are dynamically regulated and increase with increased tissue activity, hypoxia, or stress. Local adenosine concentrations thus provide a "humoral barometer" of acute changes in cellular physiology. The receptors that transduce adenosine action include A(1), A(2a), A(2b), and A(3) adenosine receptors. These receptors differ in their affinities for adenosine and in patterns of tissues expression. During development A(1) adenosine receptors (A1ARs) are especially important, and A1ARs are among the earliest receptors expressed in the embryonicbrain and heart. In the developing heart, the adenosinergic system is the dominant regulator of fetal cardiac function and A1AR activation inhibits cardiac cell division leading to cardiac hypoplasia. In the forming central nervous system, MAR activation potently inhibits the development of axons and can lead to leukomalacia. These recent data suggest that adenosine is animportant modulator of mammalian development. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:23:44