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Titolo:
Dystrophin and muscular dystrophy: Past, present, and future
Autore:
OBrien, KF; Kunkel, LM;
Indirizzi:
Harvard Univ, Childrens Hosp, Sch Med, Div Genet, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Sch Med, Div Genet, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Genet, Boston, MA USA Harvard Univ Boston MA USA ard Univ, Sch Med, Dept Genet, Boston, MA USA Harvard Univ, Childrens Hosp, Sch Med, Howard Hughes Med Inst, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 rd Hughes Med Inst, Boston, MA 02115 USA
Titolo Testata:
MOLECULAR GENETICS AND METABOLISM
fascicolo: 1-2, volume: 74, anno: 2001,
pagine: 75 - 88
SICI:
1096-7192(200109/10)74:1-2<75:DAMDPP>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-SARCOGLYCAN ADHALIN; MYOBLAST TRANSFER THERAPY; NEURAL STEM-CELLS; SKELETAL-MUSCLE; MDX MOUSE; GLYCOPROTEIN COMPLEX; EPSILON-SARCOGLYCAN; DEFICIENT MICE; BONE-MARROW; NEUROMUSCULAR-JUNCTIONS;
Keywords:
Duchenne muscular dystrophy; dystrophin; sarcoglycan; sarcospan; cell transplantation; myoblast therapy;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
134
Recensione:
Indirizzi per estratti:
Indirizzo: Kunkel, LM Harvard Univ, Childrens Hosp, Sch Med, Div Genet, Enders 570,300 Longwood Ave, Boston, MA 02115 USA Harvard Univ Enders 570,300 Longwood Ave Boston MA USA 02115 SA
Citazione:
K.F. O'Brien e L.M. Kunkel, "Dystrophin and muscular dystrophy: Past, present, and future", MOL GEN MET, 74(1-2), 2001, pp. 75-88

Abstract

Duchenne muscular dystrophy was described in the medical literature in theearly 1850s but the molecular basis of the disease was not determined until the late 1980s. The cloning of dystrophin led to the identification of a large complex of proteins that plays an important, although not yet well understood, role in muscle biology. Concomitant with the elucidation of the function of dystrophin and its associated proteins has been the pursuit of therapeutic options for muscular dystrophy. Although there is still no cure for this disorder, great advances are being made in the areas of gene introduction and cell transplant therapy. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 16:17:04