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Titolo:
Role for telomere cap structure in meiosis
Autore:
Maddar, H; Ratzkovsky, N; Krauskopf, A;
Indirizzi:
Tel Aviv Univ, Dept Mol Microbiol & Biotechnol, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 echnol, IL-69978 Tel Aviv, Israel
Titolo Testata:
MOLECULAR BIOLOGY OF THE CELL
fascicolo: 10, volume: 12, anno: 2001,
pagine: 3191 - 3203
SICI:
1059-1524(200110)12:10<3191:RFTCSI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
FISSION YEAST; MEIOTIC PROPHASE; SCHIZOSACCHAROMYCES-POMBE; CHROMOSOME SYNAPSIS; BOUQUET FORMATION; BUDDING YEAST; PROTEIN; RNA; INITIATION; TEMPLATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Krauskopf, A Tel Aviv Univ, Dept Mol Microbiol & Biotechnol, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 978 Tel Aviv, Israel
Citazione:
H. Maddar et al., "Role for telomere cap structure in meiosis", MOL BIOL CE, 12(10), 2001, pp. 3191-3203

Abstract

Telomeres, the natural ends of eukaryotic chromosomes, are essential for the protection of chromosomes from end-to-end fusions, recombination, and shortening. Here we explore their role in the process of meiotic division in the budding yeast, Kluyveromyces lactis. Telomerase RNA mutants that cause unusually long telomeres with deregulated structure led to severely defective meiosis. The severity of the meiotic phenotype of two mutants correlatedwith the degree of loss of binding of the telomere binding protein Rap1p. We show that telomere size and the extent of potential Rap1p binding to theentire telomere are irrelevant to the process of meiosis. Moreover, we demonstrate that extreme difference in telomere size between two homologous chromosomes is compatible with the normal function of telomeres during meiosis. In contrast, the structure of the most terminal telomeric repeats is critical for normal meiosis. Our results demonstrate that telomeres play a critical role during meiotic division and that their terminal cap structure isessential for this role.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 13:44:28