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Titolo:
Porins from Salmonella enterica serovar typhimurium induce TNF-alpha, IL-6and IL-8 release by CD14-independent and CD11a/CD18-dependent mechanisms
Autore:
Galdiero, M; DIsanto, M; Vitiello, M; Finamore, E; Peluso, L; Galdiero, M;
Indirizzi:
Univ Naples 2, Fac Med & Chirurg, Ist Microbiol, I-80138 Naples, Italy Univ Naples 2 Naples Italy I-80138 Ist Microbiol, I-80138 Naples, Italy
Titolo Testata:
MICROBIOLOGY-SGM
, volume: 147, anno: 2001,
parte:, 10
pagine: 2697 - 2704
SICI:
1350-0872(200110)147:<2697:PFSEST>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTI-CD14 MONOCLONAL-ANTIBODIES; NECROSIS-FACTOR-ALPHA; LPS BINDING-PROTEIN; CELL-LINE THP-1; LIPOPOLYSACCHARIDE LPS; ENDOTOXIN PROTEIN; HUMAN MONOCYTES; LIPID-A; BACTERIAL LIPOPOLYSACCHARIDES; ESCHERICHIA-COLI;
Keywords:
Salmonella typhimurium; lipopolysaccharide; cytokines; integrins; cellular receptors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Galdiero, M Univ Naples 2, Fac Med & Chirurg, Ist Microbiol, Larghetto S Aniello Caponapoli 2, I-80138 Naples, Italy Univ Naples 2 Larghetto S Aniello Caponapoli 2 Naples Italy I-80138
Citazione:
M. Galdiero et al., "Porins from Salmonella enterica serovar typhimurium induce TNF-alpha, IL-6and IL-8 release by CD14-independent and CD11a/CD18-dependent mechanisms", MICROBI-SGM, 147, 2001, pp. 2697-2704

Abstract

Lipopolysaccharide (LPS) of Gram-negative bacteria and several surface components of Gram-positive bacteria utilize CD14 and CD11a/18 as cellular receptors to induce expression and release of cytokines. of the surface components of Gram-negative bacteria, porins exhibit a biological activity similar to that of LPS. The results in this paper show that the mechanism of stimulation by porins of THP-1 cells enriched in CD14 receptor after treatment with 1,25-dihydroxyvitamin D-3 (vitamin D-3) is independent of this receptor, but is partially dependent on CD11a/18 integrins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 15:25:17