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Titolo:
Biochemical events leading to the diversion of carbon into storage lipids in the oleaginous fungi Mucor circinelloides and Mortierella alpina
Autore:
Wynn, JP; Hamid, AA; Li, YH; Ratledge, C;
Indirizzi:
Univ Hull, Dept Biol Sci, Ctr Adv Lipid Res, Kingston Upon Hull HU6 7RX, NHumberside, England Univ Hull Kingston Upon Hull N Humberside England HU6 7RX erside, England Univ Kebangsaan Malaysia, Dept Microbiol, Bangui 43600, Salangor Darul, Malaysia Univ Kebangsaan Malaysia Bangui Salangor Darul Malaysia 43600 l, Malaysia
Titolo Testata:
MICROBIOLOGY-SGM
, volume: 147, anno: 2001,
parte:, 10
pagine: 2857 - 2864
SICI:
1350-0872(200110)147:<2857:BELTTD>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
RHODOSPORIDIUM-TORULOIDES CBS-14; NIGER CITRATE SYNTHASE; CITRIC-ACID PRODUCTION; MALIC ENZYME; SACCHAROMYCES-CEREVISIAE; PYRUVATE-CARBOXYLASE; CITA OVEREXPRESSION; FILAMENTOUS FUNGI; RAT-LIVER; ACCUMULATION;
Keywords:
AMP deaminase; NAD(+); isocitrate dehydrogenase; lipid accumulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Wynn, JP Univ Hull, Dept Biol Sci, Ctr Adv Lipid Res, Kingston Upon Hull HU6 7RX, NHumberside, England Univ Hull Kingston Upon Hull N Humberside England HU6 7RX ngland
Citazione:
J.P. Wynn et al., "Biochemical events leading to the diversion of carbon into storage lipids in the oleaginous fungi Mucor circinelloides and Mortierella alpina", MICROBI-SGM, 147, 2001, pp. 2857-2864

Abstract

The biochemical events associated with the onset of lipid accumulation in Mucor circinelloides and Mortierella alpina, under conditions of nitrogen-limited growth, have been elucidated; they differ in key aspects from those described in oleaginous yeasts. The NAD(+): isocitrate dehydrogenases of Mc. circinelloides and Mort. alpina were not absolutely dependent on AMP for activity. Furthermore, changes in the cellular adenine nucleotide pools andenergy charge were different from those reported for oleaginous yeasts. InMc. circinelloides ATP, ADP and AMP concentrations all decreased by 50% after nitrogen limitation, leading to a constant energy charge at the expenseof the size of the total adenylate pool. Pyruvate carboxylase in Mc. circinelloides was cytosolic, having implications for the organization of lipid synthesis in filamentous fungi. As a result of the data obtained, a revisedand more concerted mechanism for the initiation of storage lipid accumulation is put forward for filamentous fungi.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 12:55:36