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Titolo:
Role of IL-10 in allergen-specific immunotherapy and normal response to allergens
Autore:
Akdis, CA; Blaser, K;
Indirizzi:
Swiss Inst Allergy & Asthma Res, CH-7270 Davos, Switzerland Swiss Inst Allergy & Asthma Res Davos Switzerland CH-7270 s, Switzerland
Titolo Testata:
MICROBES AND INFECTION
fascicolo: 11, volume: 3, anno: 2001,
pagine: 891 - 898
SICI:
1286-4579(200109)3:11<891:ROIIAI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
BEE VENOM PHOSPHOLIPASE-A2; T-CELL EPITOPE; PERIPHERAL-BLOOD EOSINOPHILS; INHIBITS CYTOKINE PRODUCTION; GRASS-POLLEN IMMUNOTHERAPY; IN-VITRO; PHOSPHATIDYLINOSITOL 3-KINASE; DIFFERENTIAL REGULATION; MEDIATOR RELEASE; SENSITIZED MICE;
Keywords:
interleukin-10; specific immunotherapy; tolerance; anergy; CD28;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
76
Recensione:
Indirizzi per estratti:
Indirizzo: Akdis, CA Swiss Inst Allergy & Asthma Res, CH-7270 Davos, Switzerland Swiss Inst Allergy & Asthma Res Davos Switzerland CH-7270 land
Citazione:
C.A. Akdis e K. Blaser, "Role of IL-10 in allergen-specific immunotherapy and normal response to allergens", MICROBES IN, 3(11), 2001, pp. 891-898

Abstract

Induction of specific unresponsiveness (tolerance/anergy) in peripheral T cells by interleukin-10 (IL-10) and recovery by cytokines from the tissue microenvironment represent two key steps in specific immunotherapy of allergy and in natural exposure to allergens in healthy individuals. IL-10 elicits anergy in T cells by selective inhibition of the CD28 costimulatory pathway and controls suppression and development of antigen-specific immunity. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:51:01