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Titolo:
Hypothalamic appetite-regulating neuropeptide mRNA levels in cachetic nudemice bearing human tumor cells
Autore:
Nara-ashizawa, N; Tsukada, T; Maruyama, K; Akiyama, Y; Kajimura, N; Nagasaki, K; Iwanaga, T; Yamaguchi, K;
Indirizzi:
Natl Canc Ctr, Res Inst, Div Growth Factor, Chuo Ku, Tokyo 1040045, Japan Natl Canc Ctr Tokyo Japan 1040045 Factor, Chuo Ku, Tokyo 1040045, Japan Hokkaido Univ, Lab Anat, Grad Sch Vet Med, Sapporo, Hokkaido, Japan Hokkaido Univ Sapporo Hokkaido Japan h Vet Med, Sapporo, Hokkaido, Japan
Titolo Testata:
METABOLISM-CLINICAL AND EXPERIMENTAL
fascicolo: 10, volume: 50, anno: 2001,
pagine: 1213 - 1219
SICI:
0026-0495(200110)50:10<1213:HANMLI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-EXPRESSION; MESSENGER-RNA; BODY-WEIGHT; MOLECULAR-CLONING; FOOD-INTAKE; RATS; BRAIN; ANOREXIA; PEPTIDES; CACHEXIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Tsukada, T Natl Canc Ctr, Res Inst, Div Growth Factor, Chuo Ku, 5-1-1 Tsukiji, Tokyo 1040045, Japan Natl Canc Ctr 5-1-1 Tsukiji Tokyo Japan 1040045 1040045, Japan
Citazione:
N. Nara-ashizawa et al., "Hypothalamic appetite-regulating neuropeptide mRNA levels in cachetic nudemice bearing human tumor cells", METABOLISM, 50(10), 2001, pp. 1213-1219

Abstract

We previously reported that the human melanoma cell line, SEKI, induces severe weight loss in nude mice. In the present study, we examined the expression of weight-regulating neuropeptide mRNAs in the hypothalamus of this cancer cachectic model by using a sensitive quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) method and in situ hybridization. mRNAlevels of neuropeptide Y (NPY) and corticotropin-releasing hormone (CRH) in the whole hypothalamus were elevated significantly in the SEKI mice as compared with control mice. In situ hybridization showed that NPY and CRH mRNA were upregulated in the arcuate nucleus and the paraventricular nucleus, respectively. There were no significant differences in melanin-concentrating hormone (MCH), orexin (OX), and cholecystokinin mRNA levels between the SEKI and control mice. These results suggest that the NPYergic system is functioning in the rodent model of cancer cachexia; however, the role of the CRHergic system in energy homeostasis remains to be elucidated. This is the first report of the hypothalamic neuropeptide response to each exia-inducing human cells. Copyright (C) 2001 by W.B. Saunders Company.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 00:10:48